HIV-1 and HIV-2 strains have been reported to be capable of utilising several alternative chemokine receptors
, including CCR2b, CXCR4, CXCR6 and GPR1, to mediate infection of cells.
The chemokine receptor
CXCR4 is required for outgrowth of colon carcinoma micrometastases.
Genetic deficiency of chemokine receptor
CCR5 is a strong risk factor for symptomatic West Nile virus infection: a meta-analysis of 4 cohorts in the US epidemic.
2005), resulting in a non-functional form of the chemokine receptor
The chemokine receptor
CX3CRI controls homing and antiviral potencies of CD8 effector-memory T lymphocytes in HIVinfected patients.
HIV-1 gp120 and chemokine activation of pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor
In this group of patients, the researchers found a mutation in a chemokine receptor
gene associated with a delay in HIV-1 disease progression in African-Americans and possibly also Hispanics and Native Americans, but not in Caucasians, as well as another mutation associated with an acceleration in the course of the disease.
In patients that do not respond well enough to G-CSF (up to 20% in multiple myeloma), treatment is often augmented by Plerixafor, a drug that inhibits CXCR4, a chemokine receptor
that is important in hematopoietic stem cell homing to the bone marrow.
It involves upregulation of the chemokine receptor
CCR7 and chemoinvasion towards lymphatic vessels.
They found that a chemokine known as monocyte chemoattractant protein (MCP)-1 (CCL2) and its receptor, chemokine receptor
2 (CCR2), are central to the development of pain associated with knee OA.
In addition, in both preclinical and clinical studies BKT140 had shown that by targeting the chemokine receptor
CXCR4, BKT140 also appears to have the potential to treat malignancies involving this key receptor.
Topics of the research and review papers include Nijmegen Breakage Syndrome, models of genetic and physiological heterogeneity, polymorphisms in CCR5 chemokine receptor
genes, genetic anticipation, inheritance in mammal litter sizes in different populations, heritable and molecular genetic variation in mate choice and mating-related genes, osteogenesis imperfecta, tuberous sclerosis complex, and findings in Danon disease, a rare X-linked dominant disorder.
CXCR7 is a novel chemokine receptor
whose function was discovered and characterized by ChemoCentryx.
Several years ago, researchers discovered that for the AIDS virus to infect an immune cell, HIV must grab on to a cell-surface protein called a chemokine receptor
Several chemokine receptor
molecules have also been studied including the CCR2 and CXCR4 molecules.