The CC chemokine receptor
5 (CCR5) delta 32 variant results in a non-functional form of the chemokine receptor
, which is incapable of binding beta chemokines (RANTES, MIP-1alpha, MIP-1beta).
In addition, some strains of HIV-1 can use a variety of other chemokine receptors
in studies in vitro, however it does not appear that they have major relevance to HIV infection in vivo and pathogenesis.
The report reviews C-X-C Chemokine Receptor
Type 2 (CDw128b or GRO/MGSA Receptor or High Affinity Interleukin-8 Receptor B or IL-8 Receptor Type 2 or CD182 or CXCR2) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
Chemokines and chemokine receptors
have a fundamental role in the development and regulation of immune and inflammatory responses and have received a great deal of attention in both human and experimental leishmaniasis.
CCR5 and CXCR4 chemokine receptor
expression and beta-chemokine production during early T cell repopulation induced by highly active antiretroviral therapy.
Isolating the CXCR7 receptor from potential interference by other chemokine receptors
(such as the related receptor known as CXCR4), researchers demonstrated that CXCR7 cells formed significantly larger tumors in breast and lung cancer models.
Segal notes that other kinds of cancers, such as kidney tumors, also appear to depend on the chemokine receptor
CXCR4 and so might also be thwarted by drugs blocking it.
The report reviews C-C Chemokine Receptor
Type 4 (C-C CKR-4 or K5-5 or CD194 or CCR4) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
Four of the families possess mutations in the gene for a chemokine receptor
Global Markets Direct's, 'C-C Chemokine Receptor
Type 1 (HM145 or LD78 Receptor or Macrophage Inflammatory Protein 1-Alpha Receptor or CD191 or CCR1) - Pipeline Review, H1 2016', provides in depth analysis on C-C Chemokine Receptor
Type 1 (HM145 or LD78 Receptor or Macrophage Inflammatory Protein 1-Alpha Receptor or CD191 or CCR1) targeted pipeline therapeutics.
Mogamulizumab is a new, humanised mAb directed against CC chemokine receptor
type 4 (CCR4).
It involves upregulation of the chemokine receptor
CCR7 and chemoinvasion towards lymphatic vessels.
In the study, researchers show in mouse models that statins activate the cell surface protein receptor C-C chemokine receptor
type 7 (CCR7), which in turn activates a cell-signaling pathway forcing macrophages out of plaque.
EBI1/CCR7 is a new member of dendritic cell chemokine receptor
that is up-regulated upon maturation.
The polypeptide is a human chemokine receptor
that is a member of a family of G protein-coupled receptors characterized by seven transmembrane domains.