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CD74 is a rapidly internalizing transmembrane chaperone molecule, and has high expression on human NHL and MM.
AHSP acts as a chaperone molecule -- a chemical that helps another protein to fold or unfold," said Mitchell Weiss, M.
Chaperone molecules assist with the folding process.
The UPR is a complex sequence of molecular triggers: (1) which stop the production of more protein, and (2) upregulate the production of chaperone molecules to help in folding the recently assembled protein strands.
Studies have revealed that sugars can regulate when a newly minted protein interacts with so-called chaperone molecules, which help it fold.