Inflammatory responses have long been known to disrupt BBB permeability.[sup], In parallel with this knowledge, our results revealed that downregulating NF-?B-related inflammation markedly ameliorated ultrastructural NVU damage (including neuronal, glial, and BBB damage), reduced cerebral contusion
volume, and improved neurological function in mice after TBI.
The results of this study support our hypothesis and show that the average HU of cerebral contusions
tends to decrease over time.
Inhibiting tumor necrosis factor-alpha (TNF-[alpha]) with etanercept is effective for attenuating TBI-induced cerebral contusion
, motor and cognitive dysfunction, astrocytic and microglial activation, and activated inflammation [11, 12].
The patient underwent emergency surgery, including frontal craniectomy, cleaning and extensive surgical debridement of the wound, with the removal of bone and metallic fragments and drainage of the area of the cerebral contusion
SUMMARY AND CONCLUSION: In the present study we have identified that cerebral contusion
following head injury is never an isolated event.
Intracranial complications can include intracerebral hematoma, cerebral contusion
, intraventricular hemorrhage, pneumocephalus, brain stem injury, and carotid cavernous sinus fistula.
Difference in neurotransmitter metabolism in frontotemporallobe contusion and diffuse cerebral contusion
There was no evidence of cerebral contusion
but diffuse subarachnoid hemorrhage (SAH) and comminuted fracture of occipital bone with overlying sub-galeal hematoma were seen.(Image 2) Basic supportive care, anti-epileptics and cerebral dehydrants were started and tracheostomy done to secure the airway.
Studies reveal that raised intracranial pressure (Hekmatpanah & Hekmatpanah, 1985) and cerebral contusion
(Hekmatpanah, 1970) cause microvascular obstruction associated with profound cytological alterations and damage in the brain.
The British man was taken to an Ayia Napa clinic where doctors said he had suffered cerebral contusions
Among intracranial lesions, cerebral contusions
There are many causes of hiccups including gastric distention, aerophagia, ventriculoperitoneal shunts, hydrocephalus, multiple sclerosis, strokes, epidural or subdural hematomas, diffuse axonal injury, cerebral contusions
, encephalitis, meningitis, brain abscesses, neurosyphilis, laryngitis, pharyngitis, irritation of the tympanic membrane, retropharyngeal abscess, peritonsillar abscesses, mediastinitis, esophagitis, bronchitis, pneumonia, myocardial infarction, pericarditis, aortic aneurysms, pericarditis, misplaced pacemaker wires, small bowel obstruction, perihepatitis, subphrenic abscess, goiter, tumor or cyst of the neck, barbiturates, steroids, methyldopa, and electrolyte abnormalities [1-4].
The following types of TBI were included in the analysis: subdural hematoma (SDH), epidural hematoma (EDH), cerebral contusions
(CTX), traumatic subarachnoid hemorrhages (t-SAH) and multiple trauma.
Overall, there were 65 (41.4%) cases of extradural haematoma (EDH), 42 (26.8%) cases of acute subdural haematoma (ASDH), 29 (18.5%) cases of cerebral contusions
and 21 (13.4%) cases of intra-cerebral haemorrhage (ICH).
Pathologist Dr David Scoones recorded that death was caused by cerebral contusions
and a brain haemorrhage, most likely as a result of a fall.