32] suggested that central sensitization
in knee OA is apparent among patients with high levels of pain in the absence of moderate-to-severe radiographic evidence of knee OA.
On the other hand, TMD can be considered a potential perpetuating factor for migraine because it acts as a constant nociceptive input that contributes to maintaining central sensitization
and abnormal pain processes.
In 2012 Titani was exposed to unsafe level of volatile organic compounds and a melange of particulates, fumes, dust, and unidentified stuff in her workplace, and since then has researched her resulting asthma, central sensitization
, and three central sensitivity syndromes--multiple chemical sensitivities, irritable larynx syndrome, and chronic fatigue syndrome--and sharing the information with others who may suffer from the same conditions.
The central sensitization
theory may explain these links.
But as the pain becomes chronic, an overlap of multiple mechanisms develops, with central sensitization
often playing a more dominant role than peripheral stimulation (regardless of the diagnosis).
Chronic pain conditions involve many peripheral and central sensitization
processes, from nerve endings to the brain's perception of pain.
Collectively, findings from different sources of research suggest that peripheral tissue or nerve injury may induce central sensitization
, which is associated with spinal changes that may contribute to the development of MDs.
Nijs J, Paul van Wilgen C, Van Oosterwijck J, van Ittersum M, Meeus M (2011) How to explain central sensitization
to patients with 'unexplained' chronic musculoskeletal pain: Practice guidelines.
The more vexing problem in managing rheumatologic disorders involves patients with central sensitization
and chronic pain.
The power of the central sensitization
analogy the idea that pain is best thought about as a stereo with the volume turned up--has led to the science of fibromyalgia becoming "lost in translation," according to Dr.
However, through this important case report and future research, we hypothesise that failure to fully resect these lesions at the time of TKR surgery or the development of new BMLs within the subchondral bone after TKR surgery may act as a continued peripheral nociceptive input, maintaining pain, altered central processing, and central sensitization
Treatment of Myofascial pain syndrome is difficult because it may be initiated by peripheral and central mechanisms that appear to be inter-related as Central sensitization
would lead to an increased excitability of spinal and supraspinal regions resulting from injury or inflammation-induced activation of peripheral nociceptors.
Findings published in Arthritis Care and Research, a journal of the American College of Rheumatology (ACR), further show OA patients who catastrophize"consumed by thoughts of pain"had increased central sensitization
that was associated with greater clinical pain.
TEHRAN (FNA)- Sleep disruption appears to be associated with altered pain processing and central sensitization
, according to research.
A familiar but imperfectly understood theory is that of central sensitization