The findings described in Nature resulted from the application of SB's program in genomics, or DNA research, to identifying cell-surface receptors
of a class known variously as seven-transmembrane receptors and G-protein-coupled receptors.
Among the specific topics discussed are representative classes of peptides and proteins such as enzymes, cell-surface receptors
, other membrane proteins, antibodies, fibrous proteins, and some bioactive peptide classes, as well as their various roles in misfolding-based (prion) disease, miscleavage-based disease such as Alzheimer's, missequence-based diseases, and cancer.
Follow-up research showed that this channel is a member of a family of cell-surface receptors
that sense both chemicals and temperature.
The virus isolates obtained from the tiger and the leopard contained a gLUtamine at position 222 (226 in H3) and a glycine at position 224 (228 in H3) in HA1, which were also found in other recent H5N1 isolates and which are related to preferential binding to avian cell-surface receptors
This conserved area is hypothesized to play an important role in the recognition of co lagen type IV by cell-surface receptors
In pre-clinical models, this binding prevents IL-1 from binding to cell-surface receptors
, potentially preventing a signal to the cell which can lead to inflammatory disease.
Peptide vaccines designed to block the unique cell-surface receptors
that permit immune cells to react against the body's own tissues are also under study.
Endocytosis is fundamental to GPCR biology, regulating the amount of cell-surface receptors
, helping to transduce signals from the receptor and controlling the recycling or degradation of the receptor itself.
Overexpression or hyperactivation of ErbB cell-surface receptors
drives the growth of many breast cancers.
When certain cell-surface receptors
bind a chemical stimulus, such as an opiate or a hormone, they interact with so-called G proteins.
To initiate the infection, avian influenza viruses bind to cell-surface receptors
containing terminal sialyl-galactosyl residues linked by 2-3-linkage, whereas human viruses, including the earliest available pandemic isolates, bind to receptors that contain terminal 2-6-1inked sialyl-galactosyl residues.
Fitzsimmons, "as it suggests we can use PEMF signals to activate cell-surface receptors
In many cases, IL-1 acts as a messenger to help regulate immune and inflammatory responses by attaching to cell-surface receptors
in cells that participate in the body's immune system.