Hoping to glean insights into the role of ERKs in B cell differentiation
into plasma cells, the researchers generated mice deficient in two different ERKs, ERK1 and ERK2, and studied the effect of this deficiency on the fate of B cells.
This is an exciting new approach that has the potential to increase our understanding of cell differentiation
and lead to the development of more effective vaccines and therapeutics," said George Daley, M.
We are currently advancing novel small molecule compounds from distinct, yet complementary, areas of research, including immune metabolism, cell signaling and immune cell differentiation
But science hasn't yet discovered what genes are the key players in this process, known as cell differentiation
Understanding the signalling pathways and molecular processes that lead to the genetic transitions between cell proliferation and cell differentiation
is fundamental to devising therapeutic interventions for hum, an cancer.
QBI will then apply its proprietary gene discovery technology platform to the stem cells to identify genes and proteins, such as growth factors and receptors, that are expressed during the stem cell differentiation
In this study, fish were exposed to graded concentrations of effluent continually from fertilization until 300 dph to include the full period for germ cell differentiation
in this species.
Gage's study "intersects two really important and emerging areas: noncoding RNAs and stem cell differentiation
," says Mandel.
Polymorphous low-grade adenocarcinoma of minor salivary glands: A study of 17 cases with emphasis on cell differentiation
A better understanding of the genetic mechanisms of cell differentiation
is expected to provide the basis for more precise manipulation of cell development.
The proposal also aims to determine the structure of genetic networks underlying the development and function of thymic epithelial cells and intrathymic T cell differentiation
The focus of the research at Harvard will be the mechanisms and pathways of cell differentiation
and control in embryonic development and on how drug treatment affects these mechanisms.
Topics include: molecular control of embryonic stem cell renewal, normal and cancer stem cell niches, therapeutic potential of mesenchymal stem cell differentiation
, and cancer differentiating agents in stem cell-based therapy, among others.
The suspicion that these problems may be related to PCBs' effects on the timing and type of brain cell differentiation
led to the current study.
Scientists at RIKEN, led by senior author Hiroshi Ohno, MD, PhD, teamed up with Williams' laboratory, taking advantage of a discovery by Williams that a protein called RANKL, which is produced by cells in Peyer's patches, can induce M cell differentiation