The inactivated cyclin/CDK complex is dephosphorylated and activated by the CDC25 phosphatase, so CDC25 phosphatase is an important regulator of cell cycle progression (33).
Expression of cdc25 phosphatase in germ cells of rat testis.
What it higher Plants lack a CDC25 phosphatase? Trends Plant Sci.
Elimination of cdc2 phosphorylation sites in the CDC25 phosphatase blocks initiation of M-phase.
However,
Cdc25 phosphatase activities are regulated by CDK/cyclin complexes themselves (Boutros et al., 2007).