active site

(redirected from Catalytic domain)
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  • noun

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the part of an enzyme or antibody where the chemical reaction occurs

References in periodicals archive ?
Cloning and characterization of a novel matrix metalloproteinase (MMP), CMMP, from chicken embryo fibroblasts: CMMP, Xenopus XMMP, and human MMP-19 have a conserved unique cysteine in the catalytic domain.
Activating and dominant inactivating c-kit catalytic domain mutations in distinct forms of mastocytosis.
New York, NY, 2010) from Schrodinger to evaluate the degree of exposure of phenol OH to the catalytic domain (Friesner et al.
Once in the systemic circulation, mature PCSK9 interacts with the epidermal growth factor (EGF) precursor homology domain of LDL-R on the cell surface by protein-protein interactions to the LDL-R, in a region near the PCSK9 catalytic domain (14).
Mutation detection in the nucleotide binding loop (P-loop), the catalytic domain and the activation loop of the ABL gene was performed via PCR-based dHPLC using a WAVE DNA fragment analysis system (Transgenomic).
These proteins, derived from the catalytic domain of the proteins, are supplied as activated proteins (activation by APMA is not necessary).
Recent evidence suggests that a catalytic domain fragment of MMp-2 (42kDa), but not the full-length form(62 kDa),is inhibited by lactoferrin.
The presence of two binding sites has been suggested in Manduca sexta APN, meaning that it is possible that the catalytic domain plays ah important role in receptor-toxin interaction (Masson et al.
Schering Corporation (Kenilworth, NJ) has patented a modified tumor necrosis factor-alpha converting enzyme catalytic domain, that unlike the native tumor necrosis factor-alpha converting enzyme catalytic domain, is stable at high protein concentrations.
Cysteine Residues in the Catalytic Domain of Furin are Essential for Catalytic Activity and Proper Subcellular Trafficking.
The catalytic domain of the RTKs is related to that of the cytoplasmic protein tyrosine kinases [PTKs] and the Ser/Thr kinases (Hanks and Hunter, 1995; Kruse et al.
Disruption of a critical Cys residue in the catalytic domain of SptP results in loss of phosphatase activity (38).