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(astronomy) a relatively small extraterrestrial body consisting of a frozen mass that travels around the sun in a highly elliptical orbit

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Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial.
Although the efficacy of bisoprolol, carvedilol, and metoprolol has been documented in studies that compared each of these drugs against placebo, two of these agents were compared with each other in just one reported study, the Carvedilol or Metoprolol European Trial (COMET) (Lancet 2003;362:7-13).
The Carvedilol or Metoprolol European Trial (COMET) tested 3,029 patients from 15 European countries and 317 centers over a period of six years.
The Carvedilol or Metoprolol European Trial (COMET) (27) of patients with heart failure suggested that nonselective neurohumoral ([beta] and ([alpha]) blockade may increase the benefit in comparison with selective [[beta].