Myostatin regulates cardiomyocyte
growth through modulation of Akt signaling.
With fewer of these contractile cells, known as cardiomyocytes
, the heart pumps less blood with each beat, leading to the increased mortality associated with heart disease.
The study showed that pretreatment NaHS improved mtDNA number in mouse cardiomyocyte
This experimentation might show if cardiomyocyte
genome contained a dormant stem cell regeneration site that could be coaxed for the biological repair of heart.
Besides, patient-specific iPSC-derived cardiomyocyte
application for in vitro reproduction of CVD pathologic phenotype, studying CVD molecular mechanisms, and search for new therapy methods is considered.
Therefore, in the perspective of its critical role in inflammation and cell death in cardiovascular diseases, we hypothesized that necroptosis might participate in the pathophysiological process of cardiomyocyte
hypertrophy induced by PA.
The most recent studies of cardiomyocytes
have identified the function of NO in the regulation of cardiac growth and remodeling, contractile performance, rhythmicity and metabolic rates.
This result is in agreement with a study reporting on how increased ROS production inflicts cardiomyocyte
injury by an increase in free fatty acids, apoptosis, and depletion of ATP concentrations in the hearts of diabetic patients (Tarquini et al.
Human mesenchymal stem cells isolated from the bone marrow (12) and adipose tissue (14,15) express cardiomyocyte
markers when permeabilized by streptolysin O in the presence of the rat cardiomyocyte
Heart attacks kill muscle cells called cardiomyocytes
, leaving behind tissue damage.
Roche (SIX: RO, ROG; OTCQX: RHHBY) has entered into a collaborative agreement with ChanTest Corporation, a leading ion channel screening provider, to perform cardiac safety testing of potential drug compounds using Roche's xCELLigence System RTCA Cardio Instrument and iCell[R] Cardiomyocytes
, human induced pluripotent stem (iPS) cell-derived cardiomyocytes
provided by Cellular Dynamics International (CDI).
Fibroblast growth factor has long been known to modulate cardiac morphogenesis and more recently to regulate cardiomyocyte
differentiation (Sheikh et al.
In conclusion, we found that the effects of SHS on cardiomyocyte
are mediated by the Fas death-receptor-dependent apoptotic pathway and might be related to the epidemiologic incidence of cardiac disease of SHS-exposed nonsmokers.
Once in this naive state, the cell has the potential to develop into any cell type in the body, but researchers direct it to develop into a cardiomyocyte
The technology would help researchers and commercial companies easily generate cardiomyocytes
to study their capacity for repair in heart attacks and disease.