In CPPD, ultrasound was useful in identifying
calcium pyrophosphate crystals via specific anatomic characteristics of the crystals and provided a radiation-free alternative to the conventional X-ray.
Calcium pyrophosphate crystal formation is principally dependent on the presence of extracellular inorganic pyrophosphate (PPi) mostly produced in the joints by chondrocytes.
Our patient may have been predisposed to septic arthritis by the intracellular
calcium pyrophosphate crystals found in his synovial fluid as well as his history of osteoarthritis and gout, although we could not find evidence of a definitive diagnosis of gout in the past.
The rare concurrent diagnoses included (1) forearm/hand compartment syndrome, (2)
calcium pyrophosphate crystals (pseudogout) in the wrist, (3) monosodium urate crystals, gouty tophi, and S.
Unlike in gout, there is currently no effective treatment that reduces or removes
calcium pyrophosphate crystals from a joint.
KEY WORDS: chiropractic, ankle,
calcium pyrophosphate deposition disease
Rada, "Pseudogout-associated inflammatory
calcium pyrophosphate dihydrate microcrystals induce formation of neutrophil extracellular traps," Journal of Immunology, vol.
The study's results showed that ultrasound provided excellent specificity for gout in the setting of acute
calcium pyrophosphate deposition disease (CPPD), also known as pseudogout, particularly in distinguish ing the deposition of monosodium urate on the surface of cartilage (double contour sign), and
calcium pyrophosphate within the matrix of the cartilage (interface sign).
He also discussed about
calcium pyrophosphate disease, Takayasu arteritis, Sjogren syndrome which increases the risk of developing lymphoma.
(2,3,9) Other crystal deposition diseases, which include gout (monosodium urate) and pseudogout (
calcium pyrophosphate dihydrate), are similar to acute calcific longus colli tendonitis in that they all deposit a crystalline substance into the soft tissues.
Researchers at Tehran (Iran) University of Medical Sciences randomized 61 postmenopausal women with moderate to severe knee osteoarthritis (OA) and no evidence of
calcium pyrophosphate deposition disease on x-ray to 0.5 mg twice daily of colchicine or placebo in a double-blind clinical trial.
These breakthroughs in the field of gout have given a new insight into other crystal-induced arthropathies [3] and recent international guidelines have been produced for both the treatment of gout [4, 5] and
calcium pyrophosphate deposition (CPPD) [6].
Pseudogout is a real condition, although it's often called acute
calcium pyrophosphate crystal arthritis.
Pseudo gout is caused by deposits of
calcium pyrophosphate crystals within the affected joints--usually the knee, wrist or shoulder.
