Synaptic plasticity (and the lack thereof) in hippocampal CA2
neurons, J Neurosci 27(44):12025-12032 (2007); http://dx.doi.org/10.1523/JNEUROSCI.4O94-07.2007.
While this reasoning is appealing in its simplicity, (13) it is facially inconsistent with the language of CA2
, which applies only to four situations: (1) "all cases of declared war .
The total number of pyramidal neurons in the CA1, CA2
and CA3 of any given hippocampus was estimated by multiplying the volume of the hippocampal region (as determined by the Cavalieri method) with the corresponding numerical density of neurons.
Aged neurons show higher basal internal Ca2
+ concentrations than younger neurons, and each of the calcium-dependent systems has shown abnormalities that contribute to calcium toxicity.
In the dentate gyrus and the CA1 and CA2
regions numerous symmetrical, presumably inhibitory boutons terminated on principal cell bodies.
Brain Function at the Molecular Level Aging is a multifactorial process of change, with the Ca2
+ as a common denominator.
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At the end of the study, the brain was removed from mice and normal and degenerative pyramidal neurons were counted in hippocampal CA1, CA2
, CA3 region by light microscope.
RGS14 is primarily turned on in one particular part-called CA2
-- of the hippocampus, a region of the brain known for decades to be involved in consolidating new learning and forming new memories.