Congenital CMV infection
is the number 1 cause of nonhereditary sensorineural hearing loss.
To date, most of the focus in identification of congenital CMV infection
has been linking newborn hearing testing programs with CMV testing.
The American Academy of Pediatrics, et al., states: "Female employees of childbearing age should be referred to their primary health care provider or to the health department authority for counseling about their risk of CMV infection
. This counseling may include testing for serum antibodies to CMV to determine the employee's immunity against CMV infection
...it is also important for the child care center director to inform infant caregivers/teachers of the increased risk of exposure to CMV during pregnancy" ("Caring for Our Children," AAP et al., modified 2017, nrckids.org/CFOC/Database/126.96.36.199).
It is widely accepted that T-cell mediated cellular immunity is the most important factor in controlling CMV infection
. (15) Both CD4+ and CD8+ T lymphocytes are associated with protection against CMV infection
with a complex interaction involving a CD8+ T cell response producing IFN-y as well as a number of other cytokines in response to the CMV virus.
To prevent CMV infection
and disease, transplant centers routinely employ either a prophylactic or preemptive strategy using ganciclovir or its oral prodrug valganciclovir.
The usual manifestations of overt CMV infection
at birth are hepatosplenomegaly, jaundice, thrombocytopenia and various congenital malformations, especially those involving the central nervous system.
Then he was admitted to our clinic with a prediction of possible CMV infection
While the vast majority of CMV infections
are subclinical, that does not mean the virus is inert.
Twelve patients had PCP only, 10 had CMV infection
, 2 had Cryptococcus infection, 1 had Entamoeba histolytica infection, 1 had non-tuberculous mycobacteria infection, and 1 had Toxoplasma infection.
Research has shown that people who are immuno-compromised like HIV-positive mothers are more likely to acquire CMV infection
and are more likely to transmit it to unborn babies said Dr Nancy Otieno who researches on infectious diseases at the Kenya Medical Research Institute (Kemri).Cancer patients and organ transplant recipients are also at risk of serious CMV complications.
The purpose was to evaluate the effect of accuracy of therapy with Ganciclovir and Valganciclovir (correct indication, drug dosage, duration of treatment, etc.) on the patient's outcome mainly considering the failure of antiviral therapy, recurrence or relapse of CMV infection
, organ rejection or survival, and antiviral medications' side effects.
CMV-associated IRIS usually manifests as immune recovery uveitis (IRU) or worsening retinitis; preexisting CMV infection
may rarely result in IRIS manifesting as pneumonitis, colitis, pancreatitis, or submandibular inflammation [8-10].
Our patient's CMV infection
resolved without the use of antivirals, which we attribute to recovery of the immune system.
Congenital CMV infection
results from transplacental transmission of the virus during maternal viremia.