counts were not related to the status HTLV infection, regardless of the patient's clinical status.
26) Another MACS study found that higher quotients of activated (CD38-positive) CD8 cells
predicted progression to AIDS better than CD4 count, but researchers collected these cell samples from January through June 1992, in the days of one- and two-drug therapy.
But in a small group of HIV-infected people known as long-term nonprogressors, those CD8 cells
seem to stave off the development of AIDS, even in the absence of anti-HIV drugs.
Through various tests, they found that these chemicals were produced by stimulated CD8 cells
of three of the long-term non-progressors they are studying (they picked their three best non-progressors among their patients, in order to have the best chance of identifying how their cells are able to keep HIV in check).
In a study of 30 women with stages Ia to IIa cervical cancer, low CD4 counts and reversal of the normal ratio of CD4 to CD8 cells
were associated with rapid tumor growth and the appearance of lymph node metastases, said Dr.
All 60 of those studied had CD8 cells
in their bodies.
The researchers arrived at their conclusions by measuring certain components of CD4 cells and other immune-system cells known as CD8 cells
CD4 immune cells attack disease-causing intruders, while CD8 cells
suppress the attack.
Many potential vaccines stimulate an antibody response but not the CD4 and CD8 cells
necessary for full protection from disease, says Beltz.
Specifically, rhIL-7 blocks sepsis-induced depletion of CD4 and CD8 cells
, enhances lymphocyte recruitment, prevents the sepsis-induced loss in immunity as evidenced by preserved delayed-type hypersensitivity response, does not exacerbate the proinflammatory response in sepsis, and clearly improves survival.
We will examine the effect of triggering innate responses in DC using HIV-1 mutants/drug treated wild type virus on allogeneic responses, by measurement of T cell proliferation and function and in an ex vivo CD8 T cell killing assays using peripheral blood CD8 cells
from HIV-1 infected patients.
After the infusion, the CD8 cells
in the infected mice revived and the levels of virus in their bodies decreased by a factor of four after a month.
By looking at the numbers of CD4 and CD8 cells
, checking the ratio between them and measuring the cytokine production, one can tell if a patient has HIV in only a few seconds.
The results of our study also showed that patients in meningitis/milliary group had the lowest number of CD8 cells
which was significantly different from control group.
The patients who made it to 52 weeks had an increase in these cells, with a median number that increased from 300 activated CD8 cells
per 1 million lymphocytes to 2,000 activated cells.