cytotoxic T cell

(redirected from CD8 T-cells)
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Related to CD8 T-cells: Killer T cells
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Synonyms for cytotoxic T cell

T cell with CD8 receptor that recognizes antigens on the surface of a virus-infected cell and binds to the infected cell and kill it

References in periodicals archive ?
[USA], May 18 (ANI): Researchers have shown how skin vaccination can produce protective CD8 T-cells that are recruited to the genital tissues and could be used as a vaccination strategy for sexually transmitted infections (STIs).
In the murine sepsis model, CTLA-4 expression increased not only on CD4 and CD8 T-cells but also on TReg cells.[sup][20] Anti-CTLA-4 (aCTLA-4) therapy decreased sepsis-induced apoptosis.
Studies into endocytosis via DC-SIGN observed MHC class II mediated antigen presentation [43], although more recent studies showed that DC-SIGN targeted cargo can also be cross-presented to CD8 T-cells [44].
It has been shown that CMV chronic infection in old individuals is associated with accumulations of late-differentiated CD8 T-cells, characteristic of CD8 T-cell immunosenescence, and with the development of an 'Immune Risk Phenotype' (IRP), predictive of early mortality in the elderly indicating that this virus is a major driving force of T-cell immunosenescence." (82)
Human leukocyte antigen (HLA) class I molecules present endogenously acquired antigenic peptides on the surface of infected cells to adaptive CD8 T-cells, so leading to targeted cell killing by these T cells.
Recent studies suggest that CD8 T-cells have distinctive role in immunity against Mycobacterium tuberculosis, for example they preferentially use granule exocytosis pathway and recognize heavily infected cells [5], ingest macrophages that have engulfed mycobacteria [7], secrete cytokines and lyse infected cells [6].
By using modified, non-natural peptides that stimulate both CD4 and CD8 T-cells, INNO-305 may offer an advantage over other WT1 peptide immunotherapy approaches.
On September 26 scientists at the Aaron Diamond AIDS Research Center (ADARC) announced that they had identified a significant contributor to a long-sought antiviral factor, secreted by certain CD8 T-cells, that inhibits HIV replication.
During the experiments, Gwendolyn Binder, a graduate student, observed that, using interferon-[gamma], CD4 and CD8 T-cells both successfully cleared the virus in the neurons from the spinal cord and brain stem.