In the murine sepsis model, CTLA-4 expression increased not only on CD4 and CD8 T-cells
but also on TReg cells.
A study of NK cell function in a cohort of ECs demonstrated only limited and less effective HIV-1 inhibitory capacity in vitro compared with CD8 T-cells
Proliferative capacity of epitope-specific CD8 T-cell
responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection.
They then took blood samples from HIV-infected individuals and separated out the CD8 T-cells
and the CD4 T-cells - those infected with HIV.
By using modified, non-natural peptides that stimulate both CD4 and CD8 T-cells
, INNO-305 may offer an advantage over other WT1 peptide immunotherapy approaches.
On September 26 scientists at the Aaron Diamond AIDS Research Center (ADARC) announced that they had identified a significant contributor to a long-sought antiviral factor, secreted by certain CD8 T-cells
, that inhibits HIV replication.
During the experiments, Gwendolyn Binder, a graduate student, observed that, using interferon-[gamma], CD4 and CD8 T-cells
both successfully cleared the virus in the neurons from the spinal cord and brain stem.
HLA-B27 restricted CD8 T-cells
derived from synovial fluids of patients with reactive arthritis and ankylosing spondylitis.
By removing and sorting through immune-system cells called CD8 T-cells
from AIDS patients, they plan to single out and then in the lab greatly boost the number of such cells that recognize HIV When returned to the patient, these billion extra cells should help the body stem HIV infection by recognizing and destroying any cells containing the virus, Greenberg says.