CD8 T cell

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Related to CD8 T cell: CD4 T cells, Memory T cells
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  • noun

Synonyms for CD8 T cell

T cell with CD8 receptor that recognizes antigens on the surface of a virus-infected cell and binds to the infected cell and kill it

References in periodicals archive ?
They found that those who fell more severely ill with flu had fewer CD8 T cells in their blood, and those who caught flu but had no symptoms or only mild symptoms had more of these cells.
No difference was detected between the frequency of CD4 and CD8 T cells expressing this marker (Figure 2D).
The link between CD8 T cell activation and viraemia is not clear.
Naive, effector, and memory CD8 T cells in protection against pulmonary influenza virus infection: homing properties rather than initial frequencies are crucial.
When injected into mice and guinea pigs, dl5-29 survives long enough to infect cells and trigger an immune response that includes antibodies and immune cells called CD8 T cells.
However, the reality is that most infected people make sufficient and even robust antibody and CD8 T cell responses to HIV.
Preliminary assessment of the immunological effects of CYT107 in 8 evaluable patients demonstrates a median increase in CD4 T cells exhibiting a naove or central memory phenotype of 69% over baseline, and a median increase in CD8 T cells exhibiting a naove or effector memory phenotype of 94% over baseline.
CD8 T cell CD38 expression is hugely increased in HIV infection [34] and has been shown to be an important prognostic marker in patients before they start ART, independent of CD4 count and viral load [36].
A 5-mg dose that uses the CRL 1005 adjuvant consistently showed the best results, with CD8 T cell responses in particular, in rhesus monkeys immunized at 0, 4, and 8 weeks.
One theory is that HIV-infection drives up Treg, which in turn shuts down the HIV-1- specific CD8 T cell response, he said.
Scientists have induced CD8 T cell responses against malaria, but only by using DNA- or virus-based vaccines.
The study population is defined as men and women, aged 18 years, with a confirmed diagnosis of ICL (CD4 <300 cells/L or <20% of lymphocytes on two occasions) deemed at risk for complications due to concurrent CD8 T cell lymphocytopenia and/or a history of opportunistic or otherwise serious infection, without autoimmunity or hematologic or lymphoid malignancy.
Results of a Phase I/IIa Trial in Lymphopenic HIV-Infected Patients Further Demonstrate the Potential of Interleukin-7 to Induce a Dramatic and Prolonged CD4 and CD8 T Cell Expansion, Which is Sustained for 48 Weeks
4) Subsequently published work by ADARC and collaborators has shown that viremic episodes (due to nonadherence in therapy (5) or a lack of viral suppression while on therapy (6)) were associated with stronger neutralizing antibody responses (5) and HIV-specific CD8 T cell responses (6) among patients treated during acute or early infection, respectively.