This is important for the ADXS-NEO program as Advaxis believes a number of patient tumors likely will present with hotspot mutations, and generating or maintaining CD8+ T cell
activity against these targets may increase the potential for killing cancer cells.
Additional testing showed that CD8+ T cells
were not required for the protection, but when CD4+ T and NK cells were eliminated in the mice, protection failed, indicating these two cell types were necessary to achieve the effect.
Deficiency of cytomegalovirus (CMV)-specific CD8+ T cells
in patients presenting with lateonset CMV disease several years after transplantation.
To see if attracting CD8+ T cells
into tumors helped surmount this obstacle, the researchers treated 21 patients with advanced melanoma with pembrolizumab and T-vec, an intratumorally administered, genetically modified clinical herpes simplex virus-1 strain approved for treating melanoma.
These CD8+ T cells
have been shown to play an important role in Mycobacterium tuberculosis immunity, concluded the company.
Environmental cues dictate the fate of individual CD8+ T cells
responding to infection.
Using cells from mice and human livers, Toronto General Hospital Research Institute researchers demonstrated for the first time how under specific conditions, such as obesity, liver CD8+ T cells
, white blood cells which play an important role in the control of viral infections, become highly activated and inflammatory, reprogramming themselves into disease-driving cells.
HLA class I-specific inhibitory receptors in human T lymphocytes: interleukin 15-induced expression of CD94/NKG2A in superantigen-or alloantigen-activated CD8+ T cells
. Proc Natl Acad Sci USA.
Corey, "Image analysis for accurately counting CD4+ and CD8+ T cells
in human tissue," Journal of Virological Methods, vol.
We also detected and quantified different Teff cells in the peripheral blood of patients using flow cytometry but focused our main analysis on Th17 cells, CD8+ T cells
(a surrogate phenotype for CTL), and [Foxp3.sup.+] Treg cells.
Splenocytes were enriched in either CD4+ or CD8+ T cells
by positive selection using magnetic immunoseparation (StemCell Technologies, Vancouver, Canada).
Cutting edge: Phenotypic characterization and differentiation of human CD8+ T cells
He proposes that there is a genetic deficiency of cytotoxic CD8+ T cells
that normally destroy infected B cells and control the infection:
SDF-1a is a potent inducer of HIV-1-specific CD8+ T-Cell chemotaxis, but migration of CD8+ T cells
is impaired at high viral loads AIDS Res Hum Retroviruses.