Restoration of the CD4 T cell
compartment after long-term highly active antiretroviral therapy without phenotypical signs of accelerated immunological aging.
CD4 T cell
measurements in the management of antiretroviral therapy--A review with an emphasis on pediatric HIV-infected patients.
The modern ART of HIV infection management: Towards a tailored approach to maximize CD4 T cell
STI duration and design are discrepant: in particular, the triggers for re-initiating therapy (predetermined schedule, viral load rebound, or drop in CD4 T cell
LAUSANNE, Switzerland -- A study published today online in The Journal of Experimental Medicine has identified the population of CD4 T cells
serving as the major reservoir for HIV infected cells and as the primary cell site for HIV replication and production in infected patients.
Biopsy samples obtained from the gut and respiratory mucosa during chronic infection demonstrated profound mucosal CD4 T cell
depletion in all SIV-infected animals, at levels similar to those described in the context of HIV infection.
HAART has been observed to both control HIV replication and to maintain or restore a CD4 T cell
count above 200 cells/mm3.
3) These data help explain why patients on treatment (particularly those "salvage" patients who are heavily treatment experienced with several drug-resistance mutations), no matter how high the viral load or low the CD4 T cell
count, appear to do better clinically than patients who are off treatment.
Their main job is to enable CD4 T cells
to work with other immune system agents to help direct attacks on viruses and other pathogens.
Virologic response to subsequent HAART was similar to what is expected in uncomplicated HIV disease, and the time for CD4 T cell
recovery to pretreatment levels was similar to that seen in non-HIV-infected individuals receiving similar chemotherapy.
These monkeys also maintained their CD4 T cell
counts, the scientists report in the Oct.
The partnership will initially focus on making Guava's EasyCD4(TM) system for direct, absolute CD4 T cell
counts available at five sites in rural locations in Uganda and South Africa.
OI occurred only when both IFN-[alpha] generation and CD4 T cell
counts were sufficiently depressed.
The absolute CD4 T cell
count is an essential measurement used to monitor disease progression in HIV/AIDS patients, to determine the timing of treatment with anti-retroviral drugs, and to monitor a patient's response to treatment," said Rajen Dalal, chief executive officer, Guava Technologies.
In addition, animals given the Ad5 vaccine have shown stable CD4 T cell
levels and viral control out to 2 years after SHIV challenge (see Figure).