Loss of Lrig1 leads to expansion of Brunner glands followed by duodenal adenomas with gastric metaplasia.
Nonneoplastic duodenal epithelial polyps include Brunner gland hyperplastic nodule/polyps (also known as Brunner gland hyperplasia), Brunner gland hamartomas, Brunner gland cysts, ectopic gastric mucosa, pancreatic heterotopia, hyperplastic polyps, inflammatory polyps, and hamartomatous polyps.
Brunner Gland Hyperplastic Nodules/Polyps and Brunner Gland Hamartomas
Histopathological sections showed moderately differentiated adenocarcinoma of the stomach, Infiltrating the submucosa and muscularis mucosa to a depth of 5mm.proximal duodenum showed ulcerated duodenal mucosa with lobular proliferation of brunner glands in the submucosa and few of the glands were cystically dilated.
Brunner gland hyperplasia first described by swiss physician Johann Conrad brunner.
According to Stolte, (2) in 1973, Becker (3) had drawn attention to the existence of a localized chronic pancreatitis, using the term Rinnenpankreatitis, in the German literature, but Stolte et al (2) brought the term groove pancreatitis to the English literature in 1982 with the addition of other histologic features, such as Brunner gland hyperplasia and common bile duct tubular stenosis.
* Obstruction or incompetence of the minor papilla, secondary to variable Brunner gland hyperplasia, may be involved.
The duodenum shows Brunner gland hyperplasia and variable thickening and disarray of the muscular layer, due to smooth muscle hyperplasia and fibrosis (Figure 19).
According to the most prevalent finding, paraduodenal pancreatitis has been reported as Brunner gland hamartoma, as leiomyoma or sarcoma, or as duodenal duplication.
There were also hyperplastic lobules of Brunner gland, lined by cylindrical clear mucinous cells with basal hyperchromatic nuclei (Figures 1 and 2).
Brunner gland hamartoma is a rare duodenal lesion, which was first described by Cruveilhier at the end of the 19th century.