Microscopic analysis of eyes donated by patients with AMD revealed lipid deposits within Bruch's membrane
and apoptosis of RPE cells as features of the disease that are distinct from normal aging.
In view of the limited native RPE resurfacing observed in areas of localized RPE debridement using organ cultures of aged submacular human Bruch's membrane
, ECM ligand bioavailability is likely compromised in the submacular area of aged human eyes.
With age, deposits (drusen) appear in Bruch's membrane
in the region of the macula, and represent a risk factor for ARMD.
Intraocular injection of rhPTX-2 at the time of rupture of Bruch's membrane
, and 5 and 9 days after laser resulted in an 80% reduction in CNV area compared to vehicle-injected eyes.
From retina to sclera, the choroid comprises Bruch's membrane
, the choriocapillaris, the medium diameter choroidal vessels, and the large diameter choroidal vessels.
sup] It is characterized by choroidal neovascularization (CNV) and is associated with the growth of fibrovascular tissue from the choriocapillaris through defects in Bruch's membrane
into the subretinal space.
It can also occur following traumatic disruption of the Bruch's membrane
Pseudoxanthoma elasticum (PXE) is a rare condition characterized by generalized fragmentation and progressive calcification of elastic tissue in the dermis, blood vessels and Bruch's membrane
of the eye.
Importantly, we also showed that vision can be rescued in a mouse model of Stargardt's disease, which is a form of early-onset macular dystrophy that leads to blindness despite an intact Bruch's membrane
(critical for RPE cell attachment and potential clinical efficacy).
The choroid is one of the most highly vascularised tissues in the body, located between Bruch's membrane
and the sclera.
The basic fundoscopic findings in PXE arise as a result of Bruch's membrane
Early symptoms in both types of AMD include deposition of debris known as drusen on bruch's membrane
(BM) and the appearance of extracellular matrix separating the choriocapillaries from the retinal pigment epithelium (RPE).
Campochiaro and his colleagues at Johns Hopkins conducted experiments on transgenic mice with CNV caused by an over expression of vascular endothelial growth factor in the retina and mice with laser-induced rupture of Bruch's membrane
For those with an increased risk of glaucoma, 'funny-looking' discs or suspicious cupping, the Spectralis OCT with Glaucoma Module Premium Edition software will measure the minimum rim width of the optic nerve at Bruch's membrane
The ultrastructure of the retinal pigment epithelium with observations on the choriocapillaris and Bruch's membrane