The lesion was identified as a brown tumor
of hyperparathyroidism, and the patient was referred to the endocrinology department.
presents as a fixated growing mass with bony consistency.
Baseline demographic, clinical, pathologic and treatment characteristics of the 8 regions were collected and included age, gender, residential data, symptoms, history of fracture, existence of brown tumor
, serum total Ca and p levels, serum parathormone (PTH) levels, serum 25-OH vitamin D levels, bone mineral density, size of the resected abnormal parathyroid gland(s) (largest when more than one gland was removed), histology, as well as presence of ectopia, presence of dual adenoma, and MEN- or familial-related disease.
Giant cells can also be detected in Aneurysmal bone cysts, Chondroblastoma, Brown tumors
of hyperparathyroidism, Non-ossifying fibroma and Giant cell granuloma.
Highly aggressive brown tumor
of the maxilla as first manifestation of primary hyperparathyroidism.
These include generalized osteoporosis, unilocular or multilocular cystic radiolucencies in bone (Brown tumor
), attenuation or loss of lamina dura surrounding the teeth, and calcifications in muscles and subcutaneous tissues (Figs.
Increased 18F-fluorodeoxyglucose uptake in a brown tumor
in a patient with primary hyperparathyroidism.
One of the skeletal lesions observed in PHPT is the brown tumor
also termed as Von Recklinghausen's disease of the bone or osteitis cystica fibrosa.
Huang-Hellinger, "Brown tumor
," American Journal of Roentgenology, vol.
Systemic diseases that can commonly affect the jaws include Paget's disease, osteopetrosis, Caffey's disease, eosinophilic granuloma, brown tumor
of hyperparathyroidism and, rarely, amyloid deposits.
* The spectrum of these lesions includes enchondroma, osteochondroma, hemangioma, hemangiopericytoma, enostosis, osteoid osteoma, fibrous dysplasia, Paget disease, Langerhans cell histiocytosis, aneurysmal bone cyst, eosinophilic granuloma, giant cell tumor, brown tumor
, nonossifying fibroma, and chondromyxoid fibroma.
On microscopy multi-vacuolated brown tumor
cells were identified between mature univacuolated adipocytes (Fig.
Reparative granuloma and brown tumor
of hyperparathyroidism must be included in the differential diagnosis.
Furthermore, the radiographic appearance of CGCG is not pathognomonic and may be confused with several other lesions of the jaws, such as brown tumor
of hyperparathyroidism, fibrous dysplasia, aneurysmal bone cyst, and other fibro-osseous lesions.