Five (29.4%) patients subjected to [sup]18F-FLT PET/CT imaging had negative results, including two patients with bronchioloalveolar carcinoma
, two patients with adenocarcinoma (tumor diameter <1.5 cm), and one patient with mucinous adenocarcinoma (for the region with few tumor cells and a large amount of mucous mass revealed by pathological examination, the CT value was lower than 15 Hounsfield units).
Refactory hypoxemia due to intrapulmonary shunting associated with bronchioloalveolar carcinoma
. Chest 1997; 111:1120-1121.
Researchers at the University of Alabama at Birmingham reported on 7 patients with bronchioloalveolar carcinoma
and no evidence of metastases who received transplants of either 1 or 2 cadaveric lungs following removal of all native lung tissue.
. Rev Mal Respir 2005;22(6 Pt 2):8S70-5.
The diagnosis of bronchioloalveolar carcinoma
can often pose a challenge to physicians.
Kaimori, "Bronchioloalveolar carcinoma
arising in a bronchogenic cyst," Annals of Thoracic Surgery, vol.
This includes the premalignant atypical adenomatous hyperplasia, bronchioloalveolar carcinoma
and mixed subtype adenocarcinoma (Figure 15).
Franklin et al., "Bronchioloalveolar carcinoma
and lung adenocarcinoma: the clinical importance and research relevance of the 2004 world health organization pathologic criteria," Journal of Thoracic Oncology, vol.
Cystic change (pseudocavitation) associated with bronchioloalveolar carcinoma
: A report of four patients.
Tumors with an original diagnosis of bronchioloalveolar carcinoma
were reclassified as adenocarcinoma with lepidic growth pattern per the 2015 World Health Organization criteria.
The adoption of the 2011 IASLC/ATS/ERS proposal for the classification of adenocarcinoma by the 2015 WHO classification eliminates the diagnosis of bronchioloalveolar carcinoma
. (8,11) Although the term broncioloalveolar carcinoma has been used for many decades, its imprecise definition meant that many lung cancers with differing biologic behavior and prognosis were often lumped together, including lepidic tumors that were noninvasive, lepidic tumors with minimal invasion, and invasive tumors with variable lepidic components.
Instead, the diagnostic term bronchioloalveolar carcinoma
describing this tumor that has survived for decades originated with the great Avril Liebow.
In their review, "The Demise of the Term Bronchiolo-alveolar Carcinoma" Drs Allen and Butt state, "The term bronchioloalveolar carcinoma
serves as a good example of a utile, descriptive term that, over time, with increased understanding, ran its course and attained obsolescence." Indeed, it took nearly 8 decades for the pathology community at large and pulmonary pathologists in particular to recognize that bronchioloalveolar carcinoma
with its reputation as a tumor with a "good prognosis" was in reality a form of in situ carcinoma.
Frequency of EGFR and KRAS mutations in Japanese patients with lung adenocarcinoma with features of the mucinous subtype of bronchioloalveolar carcinoma
. J Thorac Oncol.