Beginning with the 1999 WHO classification, (16) bronchioloalveolar carcinoma
was defined as an adenocarcinoma growing in a lepidic pattern along intact alveolar septa without invasion into the underlying stroma, pleura, or lymphovascular spaces (Figures 3 and 4).
Clinical pattern and pathologic stage but not histologic features predict outcome for bronchioloalveolar carcinoma
and lung adenocarcinoma: the clinical importance and research relevance of the 2004 World Health Organization pathologic criteria.
Lessons learned from mistakes and deferrals in the frozen section diagnosis of bronchioloalveolar carcinoma
and well-differentiated pulmonary adenocarcinoma: an evidence-based pathology approach.
5,16) However, the category called "adenocarcinoma with bronchioloalveolar pattern" is vague and might encompass a broad spectrum of tumors ranging from pure bronchioloalveolar carcinoma
to mixed-type adenocarcinoma with minor components of the bronchioloalveolar pattern.
Prognostic significance of thyroid transcription factor-1 expression in both early-stage conventional adenocarcinoma and bronchioloalveolar carcinoma
of the lung.
Demonstration of pathologic shunting during pulmonary angiography in a case of bronchioloalveolar carcinoma
Researchers at the University of Alabama at Birmingham reported on 7 patients with bronchioloalveolar carcinoma
and no evidence of metastases who received transplants of either 1 or 2 cadaveric lungs following removal of all native lung tissue.
This includes the premalignant atypical adenomatous hyperplasia, bronchioloalveolar carcinoma
and mixed subtype adenocarcinoma (Figure 15).
1) As explained in the manuscript focused on the aspects of this classification that focus on resection specimens, most tumors formerly classified as mucinous bronchioloalveolar carcinoma
have invasive areas, so the term proposed for these tumors is now invasive mucinous adenocarcinoma (Figure 10, A and B).
(BAC), a subtype of adenocarcinoma, forms 2.
The diagnosis of bronchioloalveolar carcinoma
requires exclusion of stromal, vascular, and pleural invasion--a requirement that demands that the tumor be evaluated histologically in its entirety.
Atypical adenomatous hyperplasia (AAH) is considered to be the adenoma in the adenoma-carcinoma sequence leading to bronchioloalveolar carcinoma
(BAC) and invasive adenocarcinoma of the lung.
of mixed mucinous and nonmucinous histology is an extremely rare entity, characterized by the occurrence of a typical BAC component associated with variable amounts of neoplastic cells exhibiting a mucinous appearance.
Genetic profile of cumulative mutational damage associated with early pulmonary adenocarcinoma: bronchioloalveolar carcinoma