They also found that an acetaminophen breakdown product
can cause glutathionylation, suggesting a new mechanism for the damage the drug causes.
Instead, depression relief comes from one of the drug's breakdown products
, a study in mice suggests.
"The vaccine effectively tracks the drug as it is metabolized, keeping the active breakdown products
out of the brain, and that, I think, explains its success," coauthor Kim Janda said in a statement Monday.
AITC is a breakdown product
of sinigrin, a chemical compound found in such brassica vegetables as mustard, cabbage, horseradish, cauliflower, sprouts, swede, kale and wasabi.
"We are not aware of any plastics that yield dioxin as a breakdown product
, absolutely none," adds Kristina Paquette of the FDA's Office of Food Additive Safety in College Park, Maryland.
Furthermore, twice the level of dichlordiphenylethylene (DDE, metabolic breakdown product
of DDT) that is claimed to cause reduced duration of lactation in humans has no adverse affect on lactation in rats (3).
The study showed that the plant chemical allyl-isothiocyanate, a breakdown product
of sinigrin, a chemical compound found in brassica vegetables, appeared to selectively target colon tumour cells in laboratory work.
A second study published in Environmental Science and Technology found that plastic resin pellets--the raw ingredient in plastics manufacturing--in the ocean rapidly absorb PCBs (previously used in electrical products), DDE (a breakdown product
of the pesticide DDT), and other toxic pollutants from ambient seawater.
Broccoli florets and young seedlings are rich sources of glucoraphanin and its breakdown product
sulforaphane, which helps protect mammals against cancer.
Radon is a naturally occurring radioactive breakdown product
of uranium that can dissolve and accumulate in groundwater.
Some researchers have also reportedly developed a test to detect if a woman's immune system is sensitive to silica, a constituent of silicone breast implants and reportedly a breakdown product
of silicone gel.
DDE, the first stable breakdown product
of DDT, occurred in 100 percent of the samples, with an average level of 4.96 ppm, and a maximum of 18.85 ppm.
In clinical cases of severe lupus, people with high levels of Factor B products in their blood responded poorly to treatment as compared to people with low blood levels of this breakdown product
. More importantly, a few people with mild lupus who appeared completely healthy but had high blood levels of Factor B products later became very ill.
He was driving a Vauxhall Astra on Colchester Avenue when he was found to have 200 micrograms of the cocaine breakdown product
BZE in every litre of blood.
For pound of fat gained, there is a 0.75% decrease in dichlorodiphenyldichloroethylene (DDE), a breakdown product
of DDT, and a 1.4% decrease in beta-HCH, a byproduct of lindane, an insecticide.