Urinary n Telopeptide range is almost fixed in the particular range once patient attains menopause unless there is bone resorption
outpaces bone formation in people who sleep less than the seven to nine hours that is recommended for adults.
P1NP and CTX are recommended by the International Osteoporosis Foundation and the International Federation of Clinical Chemistry and Laboratory Medicine as the markers of bone formation and bone resorption
, respectively., N-terminal midfragment of osteocalcin (N-MID) is a degradation product of osteocalcin and its level in the peripheral blood can reflect the activity of osteoblasts and the rate of bone mineralization.
It is a novel, stable, highly orally bioavailable gallium-based compound that selectively targets both bone tissue (preventing bone resorption
) and bone tumors (killing the tumor cells).
GLP-1 receptor-deficient mice were reported to exhibit osteopenia and increased osteoclast formation, suggesting that the GLP-1 signaling has an inhibitory effect of bone resorption
on bone metabolism .
Data on biochemical levels of calcium and measures of bone resorption
areas were subjected to normal testing and then to non-parametric statistical tests of Kruskal-Wallis and Mann Whitney, considering a significance level of 5 % (p<0.05).
Zinc, by stimulating apoptotic cell death of mature osteoclasts can inhibit bone resorption
and have direct positive effect on bone metabolism12.
BTMs can be categorized first as reflecting either bone resorption
or formation, and then further categorized into matrix products that are liberated during bone resorption
or formation or cellular products that are directly secreted into the circulation at levels commensurate with the number or activity of osteoclasts or osteoblasts (Fig.
Both doses of dried plums decreased a marker of bone resorption
Conclusion: Collectively, this study identifies aloin as a potent inhibitor of osteoclastogenesis and bone resorption
. The action of aloin was in par with alendronate sodium trihydrate and may provide evidence for its therapeutic potential to treat diseases involving abnormal bone lysis.
Subjects were followed through 1-month postpartum and the effect on urinary cross-linked N-telopeptides (NTx) of type I collagen, a specific marker of bone resorption
, was evaluated using an intent-to-treat analysis.
Maxillofacial CT showed 5x5cm cystic lesion leading to bone resorption
on the base of the nasal passage (Figure-2).
Editor's Note: Tartrate-resistant acid phosphatase (a marker of bone resorption
; increased levels of this enzyme indicate increased bone loss) and sclerostin (a protein that has anti-anabolic effects on bone formation) were lower and the ratio of bone specific alkaline phosphatase (a marker of bone formation) to tartrate-resistant alkaline phosphatase was higher after six months in the KoACT[R] group, while the control group experienced no change.
The promontory is not a common site for bone resorption
because (1) it is not an area that is involved in accumulation of cholesteatoma perimatrix substances, (2) it is the densest bone of the human body, and (3) pressure necrosis from overlying tissue is uncommon.