Bone marrow cells
were seeded onto the surfaces of titanium substrates (Ti, [NT.sub.10], [NT.sub.10]/[ICA.sub.0.5], [NT.sub.30], and [NT.sub.30]/[ICA.sub.0.5]) at an initial density of 1 x [10.sup.4]/well.
Cells are passed through a laser beam for analysis to see whether the bone marrow cells
are developing normally and to obtain an estimate of the blast (immature myeloid cell) count.
The mice bone marrow cell
micronucleus test is a sensitive indicator for study of the genetic toxicity induced by xenobiotics.
The evaluation of heptaplatin induced cytogenetic ramifications was accomplished by scrutiny of chromosomal aberrations in bone marrow cells
derived from the experimental mice.
The induction of angiogenesis by the implantation of autologous bone marrow cells
: a novel and simple therapeutic method.
In mice without grafts, few bone marrow cells
were used to repair the wound.
Later this month Shane, of Penrhyndeudraeth, Gwynedd, will go into an isolation room at Alder Hey Children's Hospital in Liverpool, where chemotherapy will kill off his own bone marrow cells
Souza, Spechler, and colleagues noted that bone marrow cells
come into play to regenerate the esophageal lining in rats that have severe reflux.
Food and Drug Administration to discuss a proposed IND to use Stemedica's proprietary line of allogeneic mesenchymal bone marrow cells
(adult human) as a treatment for ischemic stroke.
The use of bone marrow cells
to treat heart disease could move from the experimental phase and into clinical application within the next several years, as researchers move closer to developing treatments for a variety of cardiac problems.
Researchers examined the prevalence of these changes in cats without obvious clinical signs of disease ("Prevalence of hematological abnormalities and detection of infected bone marrow cells
in asymptomatic cats with feline immunodeficiency virus infection" published in Vet Microbiol).
Dr Thomas's picture 'A platelet is born' shows platelets sprouting from the surface of bone marrow cells
The tests confirmed the oral LD50 is greater than 2000 mg/kg, there was no oral toxicity in rats receiving 1000 mg/kg/day for 4 weeks, is not mutagenic to the bacteria used, did not induce either structural or numerical chromosome aberrations, did not induce micronuclei in bone marrow cells
of mice, had no skin sensitizing potential in the guinea pig maximization test, and had no toxic effects on immuno-toxicological parameters tested at 1000 mg/kg body weight/day for 4 weeks.
It is not known at this stage if the bone marrow stem cells are replacing the faulty immune system cells with ones that do not destroy the beta cells, or if the bone marrow cells
are able to support the production of new beta cells.
"Large-scale clinical-end point trials are now needed to assess the effect of intracoronary infusion of bone marrow cells
on morbidity and mortality in patients," said Dr.