One hypothesis of this huge difference of concentration between these two fluids is a possible crossing of the blood-testis barrier
only by smaller molecules.
Cheng, "Regulation of blood-testis barrier
dynamics: an in vivo study," Journal of Cell Science, vol.
The movement of preleptotene/ leptotene spermatocytes across the blood-testis barrier
(BTB), also known as the Sertoli cell barrier, during the seminiferous epithelial cycle is one of the most important cellular events taking place in the mammalian testis.
[9.] Dym M, Fawcett DW (1970) The blood-testis barrier
in the rat and the physiological compartmentation of the seminiferous epithelium.
"Differential effects of c-Src and c-Yes on the endocytic vesicle-mediated trafficking events at the Sertoli cell blood-testis barrier
: An in vitro study," American Journal of Physiology--Endocrinology and Metabolism 307(7): E553-E562.
Mruk, "The blood-testis barrier
and its implications for male contraception," Pharmacological Reviews, vol.
Orchiectomy not only provides histologic tissue for diagnosis but also removes a potential sanctuary site, as the blood-testis barrier
makes testicular tumors inaccessible to systemic therapy.
Elsewhere, Cd was also found to lead to the disruption of the blood-testis barrier
(Chung and Cheng 2001; Wong et al.
A barrier between the interstitial capillaries and the lumen of the seminiferous tubules that restricts passage of solutes from blood to the tubular compartment.
The blood-testis barrier
forms an impermeable lining around the inside of the tubule and protects vulnerable growing sperm from infections, toxins and immune system cells.
Demonstration of a functional blood-testis barrier
Sertoli cells are the major component of blood-testis barrier
; its main function is to nourish the developing sperm cells through the stages of spermatogenesis and secret many bioactive factors to affect spermatogenesis.
Cadmium chloride does not cause significant damages in the testes at a low dose of less than 3 mg/kg; however, it induces mild apoptosis of germ cells and damage to blood-testis barrier
(BTB) (12, 13).
"Rictor/mTORC2 regulates blood-testis barrier
dynamics via its effects on gap junction communications and actin filament network," FASEB Journal 27(3): 1137-1152.
Fawcett, "The blood-testis barrier
in the rat and the physiological compartmentation of the seminiferous epithelium," Biology of Reproduction, vol.