The movement of preleptotene/ leptotene spermatocytes across the blood-testis barrier
(BTB), also known as the Sertoli cell barrier, during the seminiferous epithelial cycle is one of the most important cellular events taking place in the mammalian testis.
Dym M, Fawcett DW (1970) The blood-testis barrier
in the rat and the physiological compartmentation of the seminiferous epithelium.
Cytokines, polarity proteins, and endosomal protein trafficking and signaling--The Sertoli cell blood-testis barrier
system in vitro as a study model," Methods in Enzymology 534: 181-194.
Another drug that targets sperm after they have crossed the blood-testis barrier
but before they are released into the lumen already exists.
As a result, the blood-testis barrier
was broken down (Figs.
Cadmium chloride does not cause significant damages in the testes at a low dose of less than 3 mg/kg; however, it induces mild apoptosis of germ cells and damage to blood-testis barrier
(BTB) (12, 13).
Rictor/mTORC2 regulates blood-testis barrier
dynamics via its effects on gap junction communications and actin filament network," FASEB Journal 27(3): 1137-1152.
Effects of daily dermal application of DEET and permethrin alone and in combination, on sesorimotor performance, blood-brain barrier, and blood-testis barrier
6,7) This lesion, named focal orchitis by Honore, (16) has been explained as an autoimmune process produced by an alteration of the blood-testis barrier
that permits the passage of antigens from the adluminal tubular compartment to the testicular interstitium.
Regulation of spermiogenesis, spermiation and blood-testis barrier
dynamics: Novel insights from studies on Eps8 and Arp3," Biochemical Journal 435(3): 553-562.
This might imply that these drugs have been able to permeate through the blood-testis barrier
and cause arrest of spermatogenesis (51).
In the case of the male reproductive organs, it might presumably cross the blood-testis barrier
and damage germ and Sertoli cells, thus altering normal spermatogenesis and sperm production.
Connexin 43 is critical to maintain the homeostasis of the blood-testis barrier
via its effects on tight junction reassembly," Proceedings of the National Academy of Sciences of the United States of America 107(42): 17998-18003.
Regulation of blood-testis barrier
dynamics by focal adhesion kinase (FAK): An unexpected turn of events," Cell Cycle 8(21): 3493-3499.
Connexin 43 and plakophilin-2 as a protein complex that regulates blood-testis barrier
dynamics," Proceedings of the National Academy of Sciences of the United States of America 106(25): 10213-10218.