Chemotherapy treatment of these patients kills both cancer cells and the healthy blood-forming
Source of haemopoietic (blood-forming
) stem cell transplants (HSCT)
Jude Children's Research Hospital in Memphis, Tennessee, developed an experimental gene therapy that involves inserting a normal copy of the IL2RG gene into the patient's own blood-forming
The study is one of two indicating that an antibody targeting a protein called CD117 on the surface of blood-forming
, or hematopoietic, stem cells can efficiently and safely eliminate the cells in mice and nonhuman primates.
Temporary squishiness could help drive blood-forming
stem cells out of the bone marrow and into the blood, but the cells need to be stiff to stay put and replenish the blood and immune system, Scientists at Winship Cancer Institute of Emory University, Children's Healthcare of Atlanta and Georgia Tech have found out.
The intestine's reservoir of blood-forming
stem cells was discovered when researchers noticed that the blood of patients who had received intestinal transplants contained cells from the donor.
* Stem cell transplantation: A stem cell transplant infuses healthy blood-forming
stem cells into the body.
Nenita Nenet dela Paz recently underwent an operation for abdominal hernia due to myelodysplastic syndrome, a condition characterized by inadequate blood cells and low blood count because the blood-forming
cells in the bone marrow are damaged.
In one of her blood-forming
stem cells, the chromosome carrying the mutant gene had shattered (illustrated above) and reassembled Humpty-Dumpty style, leaving out some genes, the researchers report in the Feb.
The fluid is rich in blood-forming
stem cells that can help treat some illnesses and can be stored for later use for the baby.
The biological setting for specialized blood-forming
cells that produce the infection-fighting white blood cells known as T cells and B cells has been identified by scientists at the Children's Medical Research Center, Dallas, Texas.
When a baby is born the blood remaining in the umbilical cord and placenta has blood-forming
Lee (all Mayo Clinic, Arizona) think that scientists and laboratory technicians might appreciate a succinct reference on its blood and blood-forming
tissues, as well as some of the conventional techniques for preparing samples of blood and bone marrow and examining them through light microscopes.
"Toxicity to the blood-forming
system is a key limit on drug development, so these cells could be used for safety testing in any drug development," said research leader Dr Igor Slukvin from the University of Wisconsin-Madison in the US.
The procedure replaces a patient's unhealthy blood-forming
cells with healthy cells from a donor.