We believe this research moves us one step closer toward the development of cell therapies in the blood-forming
system that don't exist today," reports Morrison, director of CMRC.
Moore said the Wisconsin researchers had taken a good first step but now need to show that their blood-forming
cells can be grafted into bone marrow and form an endless supply of new blood cells.
The growth factors and cytokines needed to stimulate and detect various blood-forming
stem and progenitor cell populations will now be incorporated into the complete line of HALO(R) Assay Kits produced by HemoGenix(R).
stem cells generate all of the red and white blood cells needed to deliver oxygen to body tissues, fight infection, and stop bleeding.
Given the potency of the effect of pleiotrophin on stem cell expansion, the authors examined whether pleiotrophin provoked blood-forming
cells to become malignant.
Bone marrow cells--the blood-forming
cells that go awry in patients with leukemia and other blood cancers--typically don't display this receptor.
In 2002, HemoGenix(R) was the first company to provide the biotechnology and pharmaceutical industry with the HALO(TM) Platform, a non-subjective and fully standardized ATP-based in vitro luminescence assay system designed to routinely determine the effects of drugs on stem cells of the blood-forming
Lead poisoning can cause permanent brain damage, permanent neurological damage, injury to blood-forming
tissues, kidney damage, convulsions, hearing loss, reproductive defects, reduced IQ, reduced attention span, behavioral problems, violence and death.
In preclinical testing CLT-008 was shown to provide hematopoetic support to enable long-term engraftment of blood-forming
stem cells, which could lead to broader use of cord blood transplants as an effective therapy for multiple life-threatening blood diseases.
Contract award: framework agreement for the supply medicines for blood and blood-forming
Toxicity to the blood-forming
system is a key limit on drug development, so these cells could be used for safety testing in any drug development," says Slukvin, who performs research at the National Primate Research Center in Madison.
The team obtained blood-forming
cells from 3 patients aged 10, 11 and 14 years old.
The scientists then repaired the original mouse's genetic defect in the stem cells and allowed the cells to mature until the team could isolate ones with blood-forming
properties similar to bone marrow of adults.
HemoGenix was the first company to provide a fully standardized ATP-based, in vitro bioluminescence assay system designed specifically as an alternative to, and in most cases a replacement for, the colony-forming cell (CFC) assay used to detect stem and progenitor cells of the blood-forming
Contract awarded for Medicinal products for the blood and blood-forming