The procedure began with doctors collecting a participants blood-forming
stem cells, after which the participant received chemotherapy and radiation to eliminate the bone marrow.
The techniques led researchers to discover that every type of blood-forming
cell in the bone marrow had distinct metabolic signatures: taking up and using nutrients in their own individual way.
In the second step, the team added genetic regulatory factors (called transcription factors) to push the hemogenic endothelium toward a blood-forming
The loop then activated gene expression that produced embryonic hemoglobin in blood-forming
cells from adult mice.
The investigation, published in Nature and led by Sean Morrison, also establishes a promising approach for mapping the entire blood-forming
Lee (all Mayo Clinic, Arizona) think that scientists and laboratory technicians might appreciate a succinct reference on its blood and blood-forming
tissues, as well as some of the conventional techniques for preparing samples of blood and bone marrow and examining them through light microscopes.
Toxicity to the blood-forming
system is a key limit on drug development, so these cells could be used for safety testing in any drug development," said research leader Dr Igor Slukvin from the University of Wisconsin-Madison in the US.
The procedure replaces a patient's unhealthy blood-forming
cells with healthy cells from a donor.
The artificial sweetener aspartame (Nutra-Sweet, Equal) caused lymphomas (cancers of the lymph system) and leukemias (cancers of the blood-forming
cells) in female--but not male--rats, according to a large Italian study.
Most porphyrin synthesis is located in either the liver or blood-forming
tissue, and blocks in either of these may lead to symptoms of porphyria.
For the first time, scientists have transformed human embryonic stem cells into primitive blood cells that are capable of maturing into specialized blood-forming
cells, an achievement that lays the foundation for new therapies using laboratory-made tissues and organs from embryonic cells.
Overexposure to lead has been shown to damage the human blood-forming
process, the nervous and reproductive systems, and the urinary tract.
First report of the Committee for Clarification of the Nomenclature of Cells and Diseases of the Blood and Blood-forming
There is good and bad news concerning leukemia, a cancer of the blood-forming
cells in the bone marrow.
Initial projects will use the LEAP Workstation to selectively process stem cells to define the factors and mechanisms that regulate the migration, expansion, and regenerative potential of adult blood-forming
(hematopoietic) and muscle-forming (myogenic) stem cells.