The lab- developed haemoglobin is a safe and portable blood substitute
The lab developed haemoglobin is a safe and portable blood substitute
While previous efforts to develop a human blood substitute
have been unsuccessful due to toxicity issues, researchers at Texas Tech University Health Sciences Center, Lubbock, are attempting to develop what could be the world's first viable substitute for human blood, as scientists have been able to identify and then nullify the source of toxicity.
HemoBioTech is engaged in the commercial development of HemoTech, a novel human blood substitute
technology exclusively licensed from Texas Tech University Health Sciences Center.
The PolyHeme study is the first allowed since similar research was halted in 1998, when more than 20 patients died after getting an experimental blood substitute
produced by Baxter Healthcare in Deerfield, IL.
Absorbance measurements (280 nm and 415 nm) of the fractions obtained from gel-filtration chromatography demonstrated that the blood substitute
contains a distribution of hemoglobin polymers with molecular weights of 100 000-600 000.
In the work on fluorocarbons, researchers are pursuing a longer-lasting blood substitute
The race lost its third major player last year when a company just a year or so away from proclaiming a successful blood substitute
halted tests abruptly--after 24 of 52 recipients died.
Although first generation blood substitutes
have failed due to toxicity problems, including a most recent FDA denial for the product PolyHeme from Northfield Laboratories, the blood substitute
technology of HemoBioTech, HemoTech, has the potential to be the first viable blood substitute
In the 1970s, the Department of Defense continued supporting the quest to develop free hemoglobin into a blood substitute
for wounded troops.
These volumes were written in an effort to provide newly introduced researchers in the field (graduate students, research fellows, and scientists) and nonspecialists with a reference that provides not only the background information and an overview on the major developments in the field but also descriptions of basic laboratory methods needed for blood substitute
Evanston, IL, has been asked by the FDA to expand the number of patients in Phase III clinical trials of its blood substitute
ADVANCES: A blood substitute
that looks like the real thing and carries oxygen just like it, but is safer and easier to store, has been successfully used in heart surgery patients, a company reported.
Moore could offer valuable assistance to HemoBioTech in the development of HemoTech as a safe blood substitute
Scientists say the discoveries could lead quickly to an effective blood substitute
and new ways of treating ailments that involve blood and tissue oxygenation, including heart attack, stroke, and sickle-cell anemia.