If we can find the daughter cell in this population that is responsible for niche formation, we may learn enough to eventually be able to expand blood stem cell numbers so that a small number, say from umbilical cord blood, can be made into enough to treat several patients with failure of blood formation
Czech scientists report they have proved that stem cells from dead donors can be transplanted to patients suffering from blood formation disorders such as leukemia, which is the first time in the world, according to Czech Science Academy press section.
The research team of Emanuel Necas and Ludek Sefc, which is from the Institute of Pathological Physiology of the 1st Medicine Faculty at Prague's Charles University, have discovered that stem cells from bone marrow, which are essential for blood formation, can be successfully transplanted even several hours after the donor's death.
They found that compounds that modulate blood flow had a potent impact on the expression of a master regulator of blood formation, known as Runx1.
The researchers showed that shear stress - the frictional force of fluid flow on the surface of cells lining the embryonic aorta - increases the expression of master regulators of blood formation, including Runx1, and of genetic markers found in blood stem cells.
This showed that biomechanical forces promote blood formation.
co-investigator on the study, commented, "Results of our preliminary tests in a mouse model of human infantile polycystic kidney disease showed that AVI's NeuGenes significantly reduced the number and size of the cysts and improved kidney function without adverse effects on body growth or blood formation
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