The blast crisis
phase is described as the rapid expansion of a population of myeloid blast cells.
14] Reported that frequency of chronic phase (CP), accelerated phases (AP) and blast crisis
(BC) were 77.
1 CML in blast crisis
is usually associated with a history of a chronic phase with basophilia and splenomegaly, as well as the BCR-ABL fusion gene.
Monitoring minimal residual disease and controlling drug resistance in chronic myeloid ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis
and shorter survival: a study by the GIMEMA Working Party on Chronic Myeloid Leukemia.
These findings indicate that the loss of miR-328 is probably essential for progression from the chronic phase of the disease to the blast crisis
stage," said principal investigator Danilo Perrotti, associate professor of molecular virology, immunology and medical genetics and a member of the Ohio State University Comprehensive Cancer Center-Arthur G.
All patients with blast crisis
relapsed within six months (Talpaz et al.
Peripheral blood samples were obtained, after receipt of informed consent, from 22 patients with accelerated phase or blast crisis
chronic myeloid leukemia.
So far in humans, it appears that only CML cases that progress to lymphoid blast crisis
(a marked increase in immature cells) or patients with Philadelphia chromosome-positive ALL are at risk for CNS leukemia," he said.
Gleevec is now approved for the treatment of patients with all 3 phases of CML-CML myeloid blast crisis
, CML accelerated phase, and CML in chronic phase, either before or after use of other therapy.
C,, has received the Health Canada approval of Gleevec(x) (imatinib mesylate), an oral therapy for the treatment of chronic myeloid leukemia (CML) in blast crisis
, accelerated phase or chronic phase after failure of interferon-alpha therapy (a current standard therapy).
The end stage of the disease, known as blast crisis
, can be fatal within several months, researchers said.
According to Radich, the disease progresses from the chronic phase into an accelerated phase, and then into the blast crisis
phase, the terminal phase of the disease during which it has the greatest resistance to treatment.
The natural history of CML evolves through a chronic and accelerated phase and terminates in blast crisis
Depending upon the type of cells involved in blast crisis
, aggressive chemotherapy may again reverse the disease.
After a chronic phase of production of too many white blood cells, CML typically evolves to the more aggressive phases referred to as accelerated phase and blast crisis