have many potential uses, they also carry risks that prescribers should recognize.
After reviewing this issue, the FDA said, it is requiring that this information be added to the drug labels of buprenorphine and methadone in addition to "recommendations for minimizing the use of [MAT] drugs and benzodiazepines
Analysis showed that benzodiazepines
were present in the deaths of 426 drug victims - up from 191 in 2015, marking a huge 123 per cent rise.
Among the changes, the FDA is requiring boxed warnings--the agency's strongest warning--and patient-focused Medication Guides for prescription opioid analgesics, opioid-containing cough products, and benzodiazepines
(nearly 400 products in total), with information about the serious risks associated with using these medications at the same time.
The new boxed warnings urge health care professionals to limit prescribing opioid pain medicines with benzodiazepines
or other central nervous system depressants only to patients for whom alternative treatment options are inadequate, and to limit dosages and treatment duration to the minimum possible while achieving the desired clinical effect.
Information regarding these risks will be included on black box warnings that will be added to drugs classified as opioids, as well as those classified as benzodiazepines
Throckmorton further noted that emergency department visits and deaths involving patients prescribed opioids and benzodiazepines
have climbed significantly over time.
are drugs typically prescribed for the treatment of neurological and/or psychological conditions, including anxiety, insomnia and seizure disorders.
detoxification has been widely used for alcohol detoxification, which is also an inhibitory substance.
Among the changes, the FDA is requiring boxed warnings the FDAs strongest warning and patient-focused Medication Guides for prescription opioid analgesics, opioid-containing cough products, and benzodiazepines
nearly 400 products in total with information about the serious risks associated with using these medications at the same time.
There were 160 people who had at least one episode of substance misuse treatment where the main substance was benzodiazepines
in 2014/15, up 19% from 135 in 2013/14, one of the biggest year-on-year increases in England.
constitute a group of psychotropic more commonly used in the clinical practice due to their four main actions: anxiolytic, hypnotic, anticonvulsive and muscle relaxant (1-3).
There were 372 deaths in England involving benzodiazepines
last year, up eight per cent.
are the dominant pharmacological agents used in the medication therapy of catatonia, but they are also very useful as diagnostic test.
The use of benzodiazepines
is common in older populations, ranging from 5% to 32% in community-dwelling older adults, (3) with incidence being much higher in aged care facilities.