The notion that physical features help guide axons
is gaining momentum, says UCLA neuroscientist Samantha Butler.
of the GABAergic D-type motor neurons of C.
Silver's lab, came up with the idea of designing a drug that would help axons
regenerate without having to touch the healing spinal cord, as current treatments may require.
Cyanine dye, DiO (3,3'-dioctadecyloxacarbocyanine perchlorate, Molecular Probes, D275), was used to trace the MLF axons
from the rhombencephalon.
The density of descending serotonergic axons
labeled by 5-HT immunostaining was dramatically reduced in the caudal spinal cord of vehicle-treated mice.
To properly form neural circuits, developing axons
(long extensions of neurons that make the nerves) need molecules to guide them towards their target, in the same way that road signs guide us when we drive," Pierre Fabre, doctoral student in Charron's team and first co-author of the article, said.
in the vpn form a major part of the 5-HT-like immunoreactive (5-HT-LIR) plexus on the pedal sole.
When testing axons
for neuro-physiological identification within a peripheral nerve, there are several kinds of large group I axons
The condition of this nerve may be an excellent indicator of whether a treatment is actually saving axons
Stem cells known as normal human neural progenitor (NHNP) cells develop into three types of brain cells: neurons, which receive and transmit electrical signals via axons
and synapses; astrocytes, which manage neurons' surrounding environment; and oligodendrocytes, which produce myelin, the fatty sheath that insulates axons
Therefore, it presents a working model to gain knowledge of how axons
migrate through intermediate regions to find their final targets and set up connections.
blebs and whorls) associated with medium- and large-diameter axons
(figures 1, A, and 1, B).
Neurons have threadlike fibers called axons
that send messages and branches called dendrites that receive them.
Neurons consist of a round cell body that sends signals over long, terminally branched processes, called axons
, and receives signals from the axons
of other neurons through multiple shorter processes, called dendrites.
This finding indicates that, as well as providing a route for axons
to travel past the injury site, our cellular bridges must contain specific factors to stimulate distant nerve cells to respond.