(AL) is caused by avian leukosis
virus (ALV) and supports the malignant proliferation in avian species (Payne et al.
Isolation and characterization of emerging subgroup J avian leukosis
virus associated with hemangioma in egg-type chickens.
Myeloid leukemia and transmission of the HPRS- 103 strain of avian leukosis
This lab continues its historical role as a leader in poultry tumor research, namely on Marek's disease, avian leukosis
, and reticuloendotheliosis.
Molecular characteristics and pathogenicity of an avian leukosis
virus isolated from avian neurofibrosarcoma.
3), (5) Marek's disease virus pp38 (primers MDCv-F/R), (4) avian leukosis
virus subtype J (primers Compton-H5/H7), (6) avian leukosis
virus subtypes A E (primers ComptonH5/AD1), (6) reticuloendotheliosis virus (primers SNVLTR-F/R), (7) and the cellular host gene glyceraldehyde-3-phosphate dehydrogenase (primers GDH-TM2.
The identification of endogenous avian leukosis
virus (ALV) and endogenous avian retrovirus (EAV) in chick cell-derived measles and mumps vaccines in current use has raised concern about transmission of these retroviruses to vaccine recipients.
Like AIDS, avian leukosis
is caused by a retrovirus.
The subgroup J avian leukosis
virus favors the myelocytic series cells and causes myeloid leukosis (myeloblastosis and myelocytomatosis).
Some 45 years ago, it was found that apparently healthy hens could transmit avian leukosis
virus (ALV) vertically in eggs (4); later it was demonstrated that live virus vaccines made in CEF were contaminated with infectious ALV (5).
In the past 2 years, a new strain of avian leukosis
virus has swept like wildfire through the broiler breeder chicken industry around the world.
7) They have been associated with implants (including transponders), local trauma, vaccine administration, radiation exposure, foreign bodies, chronic inflammation, parasitic infections (especially Spirocerca lupi in the domestic dog), and retroviral infections, such as retroendothelial virus and avian leukosis
virus in chickens.
The inoculation against subgroup J avian leukosis
virus may have a potential role in the development of testicular tumors in birds.
Formalin-fixed paraffin-embedded neoplastic tissue as well as frozen liver and spleen were negative by polymerase chain reaction for avian leukosis
virus and reticuloendo-theliosis virus.
14,15) In budgerigars with renal adenocarcinoma, an association with avian leukosis
virus infection has not been demonstrated.