The HLA-DQ8 allele is one such gene known to predispose individuals that carry it for T1D by mis-presenting autoantigens
that favor the generation and function of harmful, but not protective, immune cells.
Determination of three major islet autoantigens
- insulin, GAD65, and ICA512 (IA-2) - has become central component of studies of the natural history of DM.
Previously, we have described 81 autoantigens
identified from breast, colon, and thyroid cancers by SEREX approach [10, 12, 13, 15, 16].
Some of the autoantigens
involved in the pathogenesis of RA include IgG, collagen, proteoglycan, citrullinated proteins, fibrin, fibrinogen, and the shared human leukocyte antigen (HLA) DR epitope [6, 7].
12) On the other hand, the association between pathology and citrullinated autoantigens
is poorly defined because clinical laboratory testing of sera from RA patients is dependent on an artificial cycliccitrullinated peptide that could react with multiple citrullinated self-proteins.
Beta cells can also release autoantigens
that could start or increase an autoimmune reaction, "especially in genetically predisposed people,'' Ludviggson added.
So along with the macrophages, Chen and colleagues injected the mice with the previously attacked body proteins, called autoantigens
T cells that express the transcription factor Foxp3 restrains immune responses against autoantigens
Mechanisms of disease: Autoantigens
as clues to the pathogenesis of myositis.
4) These disorders are characterized by inflammation and production of an extensive variety of autoantibodies detected against multiple autoantigens
Type-1 diabetes (T1D) is an autoimmune disease in which pancreatic E--cells are gradually destroyed by autoreactive T-cells recognising autoantigens
(Auto-Ag) such as GAD65 and insulin.
It may prevent autoimmunity by masking the autoantigens
from the immune system or increasing their clearance .
Immunologically, the inflammatory process is thought to be mediated by T-cell and B-cell responses to CNS autoantigens
to prevent and treat autoimmunity; and
Betterle C, Dal Pra C, Mantero E Zanchetta R: Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens
, and their applicability in diagnosis and disease prediction.