13] In the hypovolemic state, prostaglandins (most importantly prostaglandin E1 and or prostacyclin) oppose the action of the vasoconstrictor autacoids
to maintain renal blood flow and glomerular filtration.
A variety of inflammatory mediators, including cytokines, autacoids
, vasoactive factors, serotonin, platelet-derived growth factors, and transforming growth factors, are released, which lead to fibrosis.
PGs are lipid- derived autacoids
that modulate many physiological systems including the central nervous system, cardiovascular, gastrointestinal, genitourinary, endocrine, respiratory, and immune systems (Hata and Breyer, 2004).
Resolvins (resolution-phase interaction products) are short-lived autacoids
, belonging to a novel family of aspirin-triggered (AT) bioactive lipids, which are synthesized during the resolution of inflammation.
Effects of cyclic AMP-elevating hormones and autacoids
on LPS-activated rat peritoneal, bronchoalveolar and hepatic (Kupffer) macrophages.