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Crystal structure of a retroviral protease proves relationship to aspartic protease family.
dendrorhous, with the ability to produce aspartic protease as its killer toxin, is a potential candidate in the search for more environmentally efficacious and toxicologically safe fungicides for the treatment of human fungal infections, particularly in immunocompromised patients.
Development of a new class of inhibitors for the malarial aspartic protease Plasmepsin II based on a central 7-azabicyclo[2.
Substrate and inhibitor profile of BACE (R-secretase) and comparison with other mammalian aspartic proteases.
Molecular cloning and functional characterization of an aspartic protease from the hard tick Haemaphysalis longicornis.
One of these proteases (Histidine Aspartic Protease, HAP) is homologous to three other aspartic proteases involved in hemoglobin metabolism but has a histidine in place of one of the two aspartic acids involved in catalysis.
Renin, an aspartic protease, is rate limiting in the generation of angiotensin (Ang) II, which is a key regulator in the maintenance of salt and water balance by regulating aldosterone secretion and blood pressure (1).
The company has two fundamental technology platforms: (i) aspartic protease inhibitors, including beta-secretase inhibitors for Alzheimer's disease; and (ii) nicotinic acetylcholine receptor (nAChR) agonists and antagonists for the treatment of angiogenesis mediated diseases and cognitive disorders.
hampei after addition of Pepstatin A, allow us to conclude that the endogenous proteolytic activity in the intestinal tract of coffee berry borer is aspartic protease type.
He applied these techniques to the design of compounds in a number of therapeutic areas, including aspartic protease inhibitors.
In the case of insects, the most common digestive proteases have been classified based on their specificity, catalytic mechanism, optimum pH and sensitivity to chemical inhibitors, defining several groups that include serine proteases, cysteine proteases, aspartic proteases and metalloproteases which are widely distributed amongst insects (Terra 1990; Terra and Ferreira 1994).
Enzymic characteristics of secreted aspartic proteases of Candida albicans.