Enterovirus 75 and aseptic meningitis
, Spain, 2005.
Of the 215 patients for whom clinical information was available, 184 (86%) had aseptic meningitis
CSF analysis showed lymphocytic pleocytosis (47 cells/[micro]L), and aseptic meningitis
of viral origin was suspected.
Initial clinical data indicate that 20 patients presented with aseptic meningitis
and 17 presented with encephalitis.
Several clues have assisted clinicians in the identification of patients with acute LCMV infection: 1) aseptic meningitis
or encephalitis during the fall--winter season, 2) a febrile illness followed by brief remission before onset of neurologic illness, and 3) CSF with a lymphocytosis and hypoglycorrachia.
The top 25 topics read by medical staff in 2003 reflected global medical concerns such as acute pulmonary embolism, diabetes, hypercholesterolemia, and anemia; while peaks in usage for topic reviews on influenza, West Nile Virus, aseptic meningitis
and human poxviruses mirrored timely health issues.
Data from a study of 27 children with Lyme meningitis (LM) and 148 children with aseptic meningitis
(AM) provide the first model to distinguish between the two conditions in areas where Lyme disease is endemic (Pediatrics 2006; 117:1-7).
Pichichero and his associates found that 58% had stomatitis (herpangina), 28% had fever with myalgias and malaise, 8% had hand-foot-and-mouth syndrome, 3% pleurodynia, 3% fever with rash, and 1% aseptic meningitis
(Pediatrics 102:1126-34, 1998).
LCMV is responsible for aseptic meningitis
and encephalitis (6) and may cause congenital malformations or abortion (7).
This retrospective review included 43 cases of nonspecific febrile illness, 61 cases of aseptic meningitis
, and 42 cases of hepatic necrosis with coagulopathy (HNC).
There were two pediatric cases: a 5-year-old child with aseptic meningitis
and a 15-year-old teenager with encephalitis.
Recurrent lymphocytic meningitis (RLM) is a rare disease, characterized by attacks of sudden onset aseptic meningitis
followed by complete recovery and unpredictable recurrences.
As the weather warms, physicians need to keep West Nile on their radar screens when confronted with a child who has flu-like or aseptic meningitis
syndromes--a fever, headache, myalgias--particularly if there are complaints or physical findings of muscle weakness.
The impact of herpes zoster infection on the central nervous system can be significant, including cranial nerve palsy, encephalitis, encephalopathy, and aseptic meningitis
Serious adverse events included grade 1 cytokine-release syndrome deemed possibly related to combination therapy, and one case each of aseptic meningitis
, autoimmune hepatitis, and pneumonitis attributed to pembrolizumab.