Urushiol might be the compound responsible for the dermatitis reactions to Metopium brownei , whereas sanguinarine is the compound associated with the toxicity of Argemone mexicana. Eddleston et al.
The mechanism of toxicity of Argemone mexicana oil might be explained by the inhibitory effects of sanguinarine on Na+/K+ATPase, induction of cell membrane damage by reactive oxygen species and lipid peroxidation, and inhibition of DNA polymerase activity, among other effects .
With the purpose of searching for new antitrichomonal agents, Xanthium brasilicum Vell and Argemone mexicana L, traditionally used for treatment of clinical signs associated with trichomoniasis such as venereal diseases, were selected to evaluate the activity of their chloroform, methanol and aqueous crude extracts against Trichomonas vaginalis trophozoites in vitro.
The whole plants of Xanthium brasilicum and Argemone mexicana were collected between January 2008 and April 2008.
I found, however, remarkable aspects of the mixing of local pharmacopoeias with other world traditional medicines even from remote areas in America, an example is the use of an American medicinal species: Argemone mexicana L.