Louis, and the chair of an APA working group that is creating a White Paper on atypical antipsychotic drugs
and metabolic risk.
The American Psychological Association, for instance, warned in an amicus brief of "serious, even severe" side effects of some antipsychotic drugs
While the proportional use of second-generation antipsychotic drugs
was found to rise from 13 to 64 per cent during follow-up, the gap in life expectancy from age 20 years between patients with schizophrenia and the general population did not widen between 1996 and 2006.
Although the mechanism underlying the sudden cardiac death in these patients is not yet known, "we believe that the most plausible explanation is that antipsychotic drugs
increase the risk of serious ventricular arrhythmias, probably through blockade of potassium channels and prolongation of cardiac repolarization.
A new wave of antipsychotic drugs
has since raised expectations for improved schizophrenia treatment.
7) There are several reports about NMS following atypical antipsychotic drugs
such as risperidone, (8) clozapine, (8) olanzapine, (8-10) and quetiapine.
Furthermore, marked improvement in TD findings arising from other antipsychotic drugs
is observed when olanzapine and clozapine are used (7).
Findings from a separate study showed that the use of atypical antipsychotic drugs
varied widely by county in Maryland, and that children aged 4-17 years who lived in counties with more practicing child psychiatrists were less likely to be prescribed an atypical antipsychotic drug
for a nonpsychotic condition, according to Dinci Pennap of the University of Maryland School of Pharmacy in Baltimore.
are the mainstay of the treatment of schizophrenia, but although they are effective in the majority of patients, approximately 30% of this population has little or no benefit from conventional antipsychotic treatment (1).
New research suggests that antipsychotic drugs
used to treat agitation, aggression, and hallucinations in people with dementia may significantly increase the risk for premature death.
The Department of Health and Human Services "has taken little action" to reduce the use of antipsychotic drugs
by older adults living outside nursing homes, the report says.
Clinical guidelines consistently suggest the use of antipsychotic drugs
for the treatment of the behavioral symptoms of dementia only when other, non-pharmacological attempts to ameliorate the behaviors have failed, and the individuals pose a threat to themselves or to others," they said.
are often used in nursing-home residents to help manage dementia and other behavioral problems, but they have been linked to fractures.
A Guide to the Extrapyramidal Side-Effects of Antipsychotic Drugs
, 2nd Edition
The Bitterest Pills--The Troubling Story Of Antipsychotic Drugs