Tinidazole, an antiprotozoal agent
that has been used in other countries for more than 25 years, also received Food and Drug Administration approval for treating giardiasis, intestinal amebiasis, and amebic liver abscess.
All three metabolites possessed toxicity on mammalian cells, which might limit their use as antiprotozoal agents
Among the topics are animal fecal actinomycetes as a new source for the discovery of drug leads, novel antimicrobial and anticancer drugs from bacteria, antimicrobial and natural compounds from edible mushrooms, antimicrobial compounds from rhizosphere bacteria and their role in plant disease management, and fighting microbe with microbe using antiprotozoal agents
derived from natural soil and aquatic actinobacteria.
Thus, most antiprotozoal agents
seem to perform poorly after nitroimidazole has failed.
The potent leishmanicidal activities of certain chemically defined molecules isolated from natural sources have become increasingly important in the search for new antiprotozoal agents
at a time when there is an urgent need for a new group of innovative medicines.
Antibacterial agents, antiprotozoal agents
, analgesics, vitamins and haematopoietic/anaemia medications were the most frequently prescribed categories of medicines in both centres.
Since the GPI anchor is a protein related to several diseases including BSE and hypophosphatasia, this achievement is expected to elucidate the mechanisms of developing those diseases, promoting the development of various drugs including antfungal, antimalarial and antiprotozoal agents
Veterinary drugs considered include five anthelminthic agents, seven antimicrobial agents, the antiprotozoal agents
, one glucocorticosteroid, one production aid and one tranquillising agent.