24) Antigen-presenting cells
subsequently present processed antigen to naive T cells, leading to the differentiation to Th1 cells, Th2 cells, Th17 cells, and cytotoxic T cells; they also induce IgA-committed B cells ([IgA.
The latter cells bind to MHC I on the antigen-presenting cells
and destroy them, whereas the former contribute to immunological memory of the activation event.
Ley said antigen-presenting cells
take up infectious organisms, foreign materials and self-proteins (in the case of autoimmune diseases) and "chop them into little pieces called epitopes" and then display the pieces on the surface of the cell.
It's mimicking some of the native molecules, but this turns out to be specific to antigen-presenting cells
, endothelial cells, and monocytes," said Dr.
For the study, pMHC molecules taken from a transgenic mouse were placed onto a red blood cell held by a micropipette, simulating the activity of antigen-presenting cells
, which normally isolate these foreign molecules and display them for recognition by T cells.
There, protein fragments of the invading pathogen are displayed on the surface of antigen-presenting cells
PDS Biotechnology's Versamune(TM) nanotechnology facilitates the uptake of disease-associated protein and peptide antigens by the antigen-presenting cells
of the immune system.
Intranasal vaccine administration could be used for gastrointestinal pathogens, and oral administration for respiratory ones, because the process proceeds in the same fashion once the antigen gains access to the antigen-presenting cells
and is taken to the [beta] cells and T cells in the lymph nodes and spleen.
1998a, b) and MHC II+ antigen-presenting cells
(APCs) (Barua and Yoshimura, 1999a; Barua et al.
Treatment with autologous antigen-presenting cells
activated with the HER-2 based antigen Lapuleucel-T: results of a phase I study in immunologic and clinical activity in HER-2 overexpressing breast cancer
Also an activation of antigen-presenting cells
, NK-cells and T-cells is obvious, and a release of different cytokines may be responsible for the various beneficial clinical effects but also the--although rarely observed--adverse reactions during this kind of therapy.
The immunotherapeutics start with precursors of the patient's dendritic cells which, when matured for the product, are currently considered the most effective antigen-presenting cells
within the immune system.
The influenza vaccine patch uses Iomai's proprietary transcutaneous immunization technology, which delivers vaccine to a group of antigen-presenting cells
in the skin called Langerhans cells.
Iomai's TCI technology uses a patch applied to the skin like a bandage and worn for several hours to deliver vaccine and/or adjuvants to a group of antigen-presenting cells
(called Langerhans cells) in the skin called that carry the vaccine to the nearby lymph nodes where they prompt a sustained immune response.
We have evidence that ethylmercury and thimerosal alter the signaling properties of antigen-presenting cells
, known as dendritic cells, at nanomolar levels.