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It is particularly significant that the B16F10 model is deficient in many antigen processing components (including tapasin, LMP-2, LMP-7, LMP10, and PA28 [alpha]/[beta]) yet expression of TAP1 function alone could lead to significant restoration of MHC Class I surface expression.
Antigen processing refers to a series of events in which engulfed mycobacterial proteins are broken down into short peptides that associate with specialised host-cell proteins, the major histocompatibility complex (MHC) molecules.
Initial experiments addressed whether PRN alters the class I major histocompatibility complex (MHC) pathway for antigen processing and presentation by antigen-presenting cells (APCs), thereby indirectly affecting effector function.
002% of the genome coding sequence to recognize, researchers in a range of medical specialties explore how pathogen molecules are converted to molecules that are targets for cell-mediated immunity, the binding of processed peptides to major histocompatibility complex (MHC) molecules, and the role of the pathogen itself in modifying the immune response by interfering with antigen processing and the downstream immune responses.
Researcners have found that Mycrobacterium tuberculosis produces a l9kDa lipoprotein that inhibits antigen processing by macrophages, allowing it to "evade T-cell effector responses and to maintain chronic infection inside host cells," a recent Reuters report notes.
It allows us to understand the trafficking events and defines the intracellular event of antigen processing.
The discovery engine selects Apitopes[TM] - Antigen Processing Independent epiTOPES.
Naturally processed HLA class II peptides reveal highly conserved immunogenic flanking region sequence preferences that reflect antigen processing rather than peptide-MHC interactions.