Each group comprised of 100 subjects labeled as Group-A (control group had healthy individuals), Group-B (newly diagnosed epileptic patients without antiepileptic
therapy), Group-C (epileptic patients on Carbamazepine therapy, which was further subdivided into C-I having epileptic patients on Carbamazepine therapy less than 1 year n=33, C-II had epileptic patients on Carbamazepine therapy 1-2 years n = 33 and C-III comprised of epileptic patients on Carbamazepine therapy more than 2 years n = 34).
Prescription of appropriate antiepileptics
according to diagnosis in optimum dosage and compliance to treatment affect control of seizures in children.
The aim of this study is to find out the prevalence and various clinical patterns of drug reactions owing to antiepileptics
, the most common clinical pattern of ACDR and the commonest AEDs responsible for the ACDR.
Therapy: During entire course of illness, 91 (59.
The findings reconfirm just how dangerous the antiepileptic
drug can be to a developing fetus, especially when viewed along with findings of increased risk associated with even low valproate doses, said Dr.
are known to be quite well tolerated and safe, but physicians and clinical pharmacists should constantly be aware of the risk of adverse effects.
loss of response (therapeutic failure) to antiepileptics
Valproic acid, in particular, stands out among older antiepileptics
for elevating risk of congenital malformations.
In contrast, the rate of suicide events for patients with depression alone was significantly higher in those who were taking antiepileptics
than in those who were not (177/100,000 person-years vs.
31, plans to discuss the data at an advisory committee meeting and will work with manufacturers of marketed antiepileptic
drugs to include the new information on product labels, the alert said.
Depakote and Depakene), a leading antiepileptic
drug currently approved for use in the treatment of epilepsy, migraine prophylaxis and bipolar disease, in preclinical studies completed to date, this stereoisomer of valnoctamide has not been associated with the safety concerns (i.
Reversed-phase HPLC (RP-HPLC) has been used to monitor antiepileptics
Before the availability of the newer antiepileptics
, almost all children with Lennox-Gastaut were uncontrolled, said Dr.
This decision is guided by assessing the risk for recurrence, the risk of injury from another seizure, the efficacy of antiepileptics
for the seizure type, and the risk associated with the antiepileptic
Market dynamics: Sales growth statistics for BPD-approved agents versus non-BPD-approved agents; sales and prescriptions of antipsychotics and antiepileptics
in the United States.