Ultrastructure of the Bunina bodies in anterior horn cells
of amyotrophic lateral sclerosis.
However, the association with limb weakness of a motor neuron or anterior horn cell
type, presence of an elevated hemidiaphragm on chest radiograph, and a restrictive pattern of respiratory failure by pulmonary function testing suggest a central, poliomyelitislike etiology for respiratory failure in all other patients.
No known infectious process limited to motor axons has been associated with the asymmetric paralysis seen in these patients, so the researchers concluded that the clinical features can be explained only by disease of the anterior horn cells
Electrodiagnostic studies of all patients displayed markedly reduced compound motor axon potentials with preserved sensory nerve action potentials; the results were interpreted as consistent with a process primarily localized to the motor axons or, far more likely, given the clinical scenario and pathologic data from WNV-infected animals, the anterior horn cells
of the spinal cord.
Thus, in the context of WNV infection, electrodiagnostic studies previously interpreted as motor axonal polyneuropathy or motor axonopathy without sensory nerve involvement (4-6) are more suggestive of anterior horn cell
loss than of Guillain-Barre syndrome.
AFP can include clinical syndromes caused by acute dysfunction of the anterior horn cells
Peripheral disorders include abnormalities in the motor unit, especially in the anterior horn cells
Clinically it presents as painful and unilateral vesicular rash in the corresponding sensory dermatomes although rarely damage to the anterior horn cells
at same level resulting in motor muscular weakness is possible.
The vessels of the anterior horn cells
i-e the anterior spinal artery shows chronic microcirculatory changes histopathologically due to constant compression on flexion.
The presenting symptoms of this case, with asymmetric paralysis, and the histologic findings of neuronophagia of motor nuclei in the anterior horn cells
are similar to disease caused by the 3 poliovirus serotypes.
In terms of the lower motor neurons, ALS affects the anterior horn cells
of the spinal cord, leading to limb weakness.