The symptomatic management of migraine commonly administers simple analgesics (e.g., aspirin and acetaminophen), combination analgesics (e.g., Midrin and Excedrin Migraine), butalbital-containing medications, or nonsteroidal anti-inflammatory drugs (NSAIDs) including naproxen sodium (Anaprox, Aleve), meclofenamate (Meclomen), ibuprofen (Advil), flurbiprofen (Ansaid
), and ketorolac (Toradol).[44,67] In addition to the drugs mentioned above, muscle relaxants, antispasticity medications, dopamine antagonists, corticosteroids, and opioids may be suggested as backup agents when other medications do not provide headache relief.
Upjohn has also acquired licenses that later became top-selling products like "Motrin" and "Ansaid
", both anti-inflammatory pharmaceutical licensed from the Boots Company, England, and "Orinase" and "Micronase" anti-diabetics, licensed from the Hoechst GmbH, Germany.
One, flurbiprofen, is a substitute in tablet form for Upjohn Co.'s nonsteroidal anti-inflammatory Ansaid
. The other, mexiletine, is a substitute in capsule form for Boehringer-Ingelheim Pharmaceuticals Inc.'s antiarrhythmic Mexitil.