Can animal models
be replaced with human cellular models in drug discovery?
In: Animal Models
in Psychopathology (Bond NW, ed).
The platform will advance the understanding of type 1 diabetes in the NOD mouse and permit the translation of data and results generated from that animal model
into likely human responses under similar conditions (i.
Dr Deborah Rathjen, CEO and Managing Director of Bionomics, stated, "This new animal model
is a valuable addition to our unique and extensive portfolio of intellectual property in the field of epilepsy and ion channels.
Nevertheless, the fact that clinically effective anticraving and antirelapse compounds reduce the alcohol deprivation effect in our animals lends predictive value to this animal model
for the development of new and better drugs for the treatment of alcoholism [Spanagel et al.
MCT-175 successfully ameliorated the disease in animal models
However, research is needed in provide for a full array of totipotent and multipotent stem cells from nonhuman biomedical research animal models
, as well as to provide the research tools to identify, characterize, and purify those cells.
Specific scientific priorities that remain to be addressed include 1) obtaining further sequence data from the terminal regions of additional variola isolates, 2) continuing efforts to effectively detect variola virus infection and validate these procedures, 3) developing new drugs for smallpox treatment, 4) developing less reactogenic vaccines to protect against smallpox infection, and 5) validating an animal model
of human smallpox to allow assessment of candidate drugs and vaccines for both efficacy and regulatory purposes.
Currently, all testing of such compounds is primarily done in vitro or in an animal model
lacking critical human processes.
At present, researchers have no animal model
for testing potential therapies for the disorder or for studying the feasibility of inserting genes for normal hemoglobin production into sickle cell patients.
Any non-mammalian or mammalian animal model
may be used, as long as it contributes to the common overall theme or objective of the program project.
A major goal of the current research is to define an animal model
that faithfully replicates human smallpox.
In one animal model
, MPL-C was found to enhance preservation of the energy charge in myocardial tissue and in a second animal model
reduced infiltration by neutrophils into the border regions of the infarct area.
They report the first successful spread of HIV infection in human thymus and lymph nodes in an animal model
Preliminary studies suggest these compounds provided benefit in the SJL female mouse model of EAE, a widely used animal model
of multiple sclerosis.