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The ideal animal model
of a disease would parallel the full spectrum of its characteristics and a matching time course in the evolution of changes in patients (Pouladi, Morton, & Hayden, 2013).
Ex-vivo animal models
have proved to be useful in the training of various other well-established endoscopic procedures, such as endoscopic haemostasis, endoscopic ultrasound, endoscopic retrograde cholangiopancreatography and endoscopic submucosal dissection.6 The evidence shows training on animal models
improves procedural skill, aids the application of endoscopic techniques in clinical practice and increases confidence within trainees.6 Furthermore, 1-day training courses on an ex-vivo animal model
have been shown to improve endoscopic resection skill, insertion of stents and application of over-the-scope (OVESCO) clips.7
Also reviewed are neuroimaging findings in animal models
of alcoholism and related neurological disorders.
have been used to evaluate the pathogenesis of periodontal diseases and various periodontal treatment modalities.
After years of research, a reliable animal model
has been found.
preferred for research are rodents, dogs, cats, primates.
Cell safety studies differ in design from traditional drug safety studies by specific variables such as animal model
compatibility with the (foreign) cell test article; for instance, traditional drug programmes usually employ healthy animals.
807) created a two-hit [neuroinflammation and mutant [alpha]-synuclein ([alpha]-syn) overexpression] animal model
to investigate mechanisms through which mutant [alpha]-syn and inflammation work in concert to mediate chronic PD neurodegen-eration.
* The preventative effect or reduction is demonstrated in more than one animal species expected to react with a response predictive for humans, unless the effect is demonstrated in a single animal species that represents a sufficiently well-characterized animal model
for predicting the response in humans.
Japan Science and Technology Agency (Kawaguchi-shi, Japan) has patented a animal model
useful in identifying a molecule controlling in a lymphocyte-specific manner migration and thus elucidating immune-related diseases and pathogenic conditions such as allergy, autoimmune diseases, GvH and graft rejections at a molecular level, or in developing a novel therapy.
Researchers there will conduct a clinical trial of an 11-herb Chinese formula known as HLXL for osteoarthritis of the knee; assess acupuncture's effect on inflammatory pain in an animal model
; and study the efficacy of HLXL in an animal model
of autoimmune arthritis.
To create an animal model
of preeclampsia, Osol and his colleagues injected pregnant rats with a drug that inhibits blood vessels from releasing nitric oxide, a molecule that normally relaxes vessels so that they can expand.
A small animal model
would be very valuable for HIV/AIDS vaccine testing, investigating HIV pathophysiology, and exploring anti-HIV therapeutics.
The goal of this three-year study is to create an animal model
of tinnitus in the CBA strain of mouse, which have excellent hearing abilities, without compromising other auditory functions.