14 Issue 1), the Company describes its recent progress in the development of HDAC inhibitors for oncology, which includes hydroxamic acids, anilides
, TSA-like straight chain derivatives, and 2-aminophenylamides of omega-substituted alkanoic acids.
Despite the analytical efforts seeking toxic substances in these oils, only aniline derivatives such as fatty acid anilides (1,3,17,18) and fatty acid esters of 3-phenylamino-1, 2-propanediol (PAP esters) (19-21) have been identified in toxic oil batches.
Anilides and PAP esters identified in oil batches should be considered arylamides and arylamines, respectively.
The field of inhibiting HDACs has emerged as a novel human anticancer strategy and MethylGene has developed multiple series of small molecule inhibitors of HDACs, including sulfonamide hydroxamic acids and anilides
, as described in the Company's recently accepted chemistry paper entitled "Development of potential antitumor agents.
2002, 45, 2877-2885) MethylGene describes the design, synthesis and biological results of a new series of sulfonamide anilides
and trichostatin A analogues as potent HDAC inhibitors, respectively.