In recent years, angiogenic proteins such as fibroblast growth factor, have generated great interest among academic researchers and pharmaceutical and biotechnology companies as biological approaches to treating cardiovascular disease.
This delivery modality mimics endogenous processes that drive angiogenesis and overcomes two major shortcomings associated with systemic delivery of recombinant angiogenic proteins, their potential systemic toxicity and short half-life.
In recent years, angiogenic proteins such as fibroblast growth factor, have generated great interest as biological approaches to treating cardiovascular diseases by stimulating the growth of new blood vessels," said Spiros Jamas, Sc.
The walls of blood vessels are made up of endothelial cells which, when activated by angiogenic proteins such as VEGF (Vascular Endothelial Growth Factor), migrate towards the disease that sent out the angiogenic signals.
Chairman, Cardiology Research Foundation, Washington Hospital Center, noted: "Direct injection of genes encoding for angiogenic proteins or injection of the proteins themselves, is a very promising new concept in the treatment of coronary artery disease.