But new research suggests certain angiogenesis inhibitors may actually promote the growth of tumours.
Scientists made the discovery after studying cilengitide, an experimental angiogenesis inhibitor which has not yet been licensed for patients.
PI-88 is a compound that is unique among other angiogenesis inhibitors
, and we are looking forward to investigating its potential in treating cancer patients," Dr.
Her paper, "Angiogenesis Inhibitors
Endostatin or TNP-470 Reduce Intimal Neovascularization and Plaque Growth in Apolipoprotein e-Deficient Mice," showed that the growth of the small blood vessel network feeding coronary artery plaques in mice could be reduced by giving them an angiogenesis inhibitor
Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that, depending on the tumor type, approximately one-quarter to one-third of surveyed Brazilian and Mexican oncologists' patients who are eligible for treatment with angiogenesis inhibitors
do not receive such therapy, primarily because of reimbursement and/or budget-related factors.
Rupnick and her colleagues have ruled out the possibility that angiogenesis inhibitors
simply made the mice sick or spoiled their taste for food.
The prostate cancer market is reaching maturity, and major players' sales have been eroded by the launch of various LHRH agonist depot formulations, we identify that angiogenesis inhibitors
will be the most promising for future treatment of prostate cancer.
The major products segments analyzed are Angiogenesis Inhibitors
, and Angiogenesis Stimulators.
Several new agents in development seek to achieve this goal, including immune system modulators (such as MAbs and immunotoxins), cell-cycle inhibitors, proteasome inhibitors, apoptosis inducers, and angiogenesis inhibitors
The ability of HDAC inhibitors to synergize with classic chemotherapeutic agents as well as newer signal transduction pathway modulators and angiogenesis inhibitors
represents an increasingly appreciated concept meaning that in contrast to the current wave of targeted therapies, the utility of HDAC inhibitors could span multiple cancers and be used alongside a broad range of therapeutics.
Approval of these drugs essentially validated the concept of angiogenesis, and interest in developing angiogenesis inhibitors
However, opinion leaders have identified angiogenesis inhibitors
to be the most promising for prostate cancer.
The report highlights commercial opportunities for angiogenesis inhibitors
such as new therapeutic modalities in cancer, ophthalmic diseases, vascular skin diseases, and chronic inflammatory diseases.
What I find particularly exciting, given their different but complimentary mechanisms of action, is the notion of combining vascular targeting agents with angiogenesis inhibitors
, and other standard treatments.
The Company's three programs include growth factor blockers, angiogenesis inhibitors
and cancer vaccines.