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  • noun

Words related to angiogenesis

the formation of new blood vessels

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The corneal angiogenesis assay involves creating a pocket in the cornea of a rabbit or mouse wherein test tumors or tissues are placed to induce the development of vasculature (Gimbrone et al.
It is a well-known fact that cells in vitro both gain and lose attributes found in vivo, and it is generally not feasible to use truly primary (not passaged) endothelial cells in angiogenesis assays.
The results demonstrated that Defibrotide at concentrations corresponding to pharmacological Defibrotide blood levels (100 og/mL) reduced vessel formation, which could be confirmed by two classical in vitro angiogenesis assays (tube formation in matrigel, rat aortic ring sprouting).
This result could be confirmed by alternative in vitro angiogenesis assays.
Various in vitro (endothelial cells proliferation assay, endothelial cells migration assay, tube formation assay and aortic ring assay) and in vivo (matrigel plug assay, corneal angiogenesis assay and CAM assay) methods are available to evaluate pro-angiogenic and anti-angiogenic potentials of molecules (Auerbach et al.